Biosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues
Description: This project aims to uncover the reengineering potential of the biosynthetic machinery that produces glycopeptide antibiotics by advancing our understanding of how the core peptide production line functions. Natural product biosynthesis often produces complex peptide structures, with one important example being the glycopeptide antibiotics. This project expects to generate new knowledge about enzymatic peptide biosynthesis using a highly interdisciplinary approach and previously developed tools. The anticipated outcomes of this project will be an enhanced understanding of how such complex peptide biosynthesis is performed, which is knowledge vital for future efforts to reengineer such biosynthetic peptide assembly lines as a series of modular LEGO blocks to produce new bioactive peptides.
Funder: Australian Research Council
Amount: A$505,400
Funding type: research
Funder scheme: Discovery Projects
Start date: 2019-01-01
End date: 2021-12-31
Investigator: Max Cryle
Institution: Monash University
Funded outputs count: 9
Funder award ID: DP190101272
OpenAlex ID: G8090326944