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Migration and function of Th17 cells in the gut

Description: Th17 cells have recently been recognized as a major lineage of immune cells that regulate inflammation in the body. The research aims to provide novel strategies to control the migration and function of Th17 cells in the intestine, which is particularly relevant to inflammatory bowel diseases. The outcomes can also be applied to control of Th17-cell-regulated inflammation and immunity in other tissues. Public
Funding type: research
Funder scheme: R56
Start date: 2009-09-15
End date: 2010-07-31
Investigator: CHANG H KIM
Institution: PURDUE UNIVERSITY
Subfield: Immunology
Funded outputs count: 12
Funder award ID: R56AI080769
OpenAlex ID: G8094053593
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
2021 · Chang H. Kim · Cellular and Molecular Immunology · 414
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B cell-helping functions of gut microbial metabolites
2016 · Chang Kim · Microbial Cell · 33
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Human Tfh and Tfr Cells: Identification and Assessment of Their Migration Potential
2015 · Chang H. Kim, Seika Hashimoto-Hill, et al. · Methods in molecular biology · 6
Cutting Edge: Progesterone Directly Upregulates Vitamin D Receptor Gene Expression for Efficient Regulation of T Cells by Calcitriol
2014 · Shankar Thangamani, Myughoo Kim, et al. · The Journal of Immunology · 30
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Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice
2013 · Myung H. Kim, Seung G. Kang, et al. · Gastroenterology · 1,165
Retinoic acid promotes the development of Arg1‐expressing dendritic cells for the regulation of T‐cell differentiation
2013 · Jinsam Chang, Shankar Thangamani, et al. · European Journal of Immunology · 56
Progesterone suppresses the m TOR pathway and promotes generation of induced regulatory T cells with increased stability
2012 · Jee H. Lee, John P. Lydon, et al. · European Journal of Immunology · 121
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Progesterone Promotes Differentiation of Human Cord Blood Fetal T Cells into T Regulatory Cells but Suppresses Their Differentiation into Th17 Cells
2011 · Jee H Lee, Benjamin Ulrich, et al. · The Journal of Immunology · 222
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Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells
2010 · S G Kang, J Park, et al. · Mucosal Immunology · 77
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Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine
2010 · Chuanwu Wang, Seung G Kang, et al. · The Journal of Immunology · 104
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Homeostatic and pathogenic extramedullary hematopoiesis
2010 · Chang Kim · Journal of Blood Medicine · 255
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Reining in FoxP3+ regulatory T cells by the sphingosine 1‐phosphate‐S1P1 axis
2009 · Chang H Kim · Immunology and Cell Biology · 5
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