Award

Mosquito larval immunity and its impact on gut microbiota and malaria competence

Description: Mosquito larva-bacterium interactions contribute to the evolution of immune system. This proposed project initiates a study on larval immune responses upon exposure to larvicidal bacterium Bacillus sphaericus and its impact on mosquito gut microbiota and malaria susceptibility. This pilot project will generate data towards comprehensive understanding the tripartite ecological interactions among malaria, gut microbiota and host immunity and its impact on vectorial capacity.

Funder: National Institute of General Medical Sciences

Funding type: grant

Funder scheme: SC2

Start date: 2011-03-01

End date: 2014-02-28

Investigator: JIANNONG XU

Institution: NEW MEXICO STATE UNIVERSITY LAS CRUCES

Topic: Insect symbiosis and bacterial influences

Subfield: Insect Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Funded outputs count: 14

Funder award ID: SC2GM092789

OpenAlex ID: G8174552932

Redox state affects fecundity and insecticide susceptibility in Anopheles gambiae

2018 · Cody J. Champion, Jiannong Xu · Scientific Reports · 31

Investigation of the seasonal microbiome of Anopheles coluzzii mosquitoes in Mali

2018 · Benjamin J. Krajacich, Diana L. Huestis, et al. · PLoS ONE · 67

Anopheles gambiae: Metabolomic Profiles in Sugar‐Fed, Blood‐Fed, and Plasmodium falciparum‐Infected Midgut

2017 · Cody J. Champion, Phanidhar Kukutla, et al. · Dataset Papers in Science · 10

The impact of metagenomic interplay on the mosquito redox homeostasis

2016 · Cody J. Champion, Jiannong Xu · Free Radical Biology and Medicine · 37

The waaL gene mutation compromised the inhabitation of Enterobacter sp. Ag1 in the mosquito gut environment

2015 · Dong Pei, Jinjin Jiang, et al. · Parasites & Vectors · 19

Historical survey of the kdr mutations in the populations of Anopheles sinensis in China in 1996–2014

2015 · Yan Wang, Wanqin Yu, et al. · Malaria Journal · 25

Statistical Approach of Functional Profiling for a Microbial Community

2014 · Lingling An, Nauromal Pookhao, et al. · PLoS ONE · 4

Insights from the Genome Annotation of Elizabethkingia anophelis from the Malaria Vector Anopheles gambiae

2014 · Phanidhar Kukutla, Bo G. Lindberg, et al. · PLoS ONE · 75

Draft Genome Sequences of Elizabethkingia anophelis Strains R26 T and Ag1 from the Midgut of the Malaria Mosquito Anopheles gambiae

2013 · Phanidhar Kukutla, Bo G. Lindberg, et al. · Genome Announcements · 29

A video clip of the biting midge Culicoides anophelis ingesting blood from an engorged Anopheles mosquito in Hainan, China

2013 · Yajun Ma, Jiannong Xu, et al. · Parasites & Vectors · 24

Depletion of Ribosomal RNA for Mosquito Gut Metagenomic RNA-seq

2013 · Phanidhar Kukutla, Matthew Steritz, et al. · Journal of Visualized Experiments · 17

Draft Genome Sequence of Pseudomonas sp. Strain Ag1, Isolated from the Midgut of the Malaria Mosquito Anopheles gambiae

2012 · Celeste Alvarez, Phanidhar Kukutla, et al. · Journal of Bacteriology · 17

Draft Genome Sequences of Enterobacter sp. Isolate Ag1 from the Midgut of the Malaria Mosquito Anopheles gambiae

2012 · Jinjin Jiang, Celeste Alvarez, et al. · Journal of Bacteriology · 19

Dynamic Gut Microbiome across Life History of the Malaria Mosquito Anopheles gambiae in Kenya

2011 · Ying Wang, Thomas M. Gilbreath, et al. · PLoS ONE · 577