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RGS14 regulation of synaptic plasticity in hippocampal neurons

Description: Project narrative: These studies will define novel molecular mechanisms that underlie normal physiological processes such as learning and memory that are altered in human disease states such as schizophrenia or the autism and bipolar spectrum of disorders.
Funding type: research
Funder scheme: R01
Start date: 1997-12-01
End date: 2024-05-31
Investigator: JOHN R HEPLER
Institution: EMORY UNIVERSITY
Funded outputs count: 53
Funder award ID: R01NS037112
OpenAlex ID: G8304852425
Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice
2025 · Sara N. Bramlett, Stephanie L. Foster, et al. · Addiction Neuroscience · 3
Regulator of G protein signalling 14 (RGS14) protein expression profile in the adult mouse brain
2024 · Sara N. Bramlett, Shana M. Fitzmaurice, et al. · European Journal of Neuroscience · 1
RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus
2023 · N.H. Harbin, D.J. Lustberg, et al. · Neurobiology of Disease · 12
RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease
2022 · Carolina Montanez‐Miranda, Sara N. Bramlett, et al. · Hippocampus · 12
Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
2022 · Carolina Montañez-Miranda, Riley E. Perszyk, et al. · Molecular Pharmacology · 2
RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein
2022 · Peter A. Friedman, W. Bruce Sneddon, et al. · Journal of Biological Chemistry · 20
RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures
2021 · Stephanie L. Foster, Daniel J. Lustberg, et al. · Psychopharmacology · 10
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RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain
2021 · Nicholas H. Harbin, Sara N. Bramlett, et al. · International Journal of Molecular Sciences · 23
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Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons
2020 · Katherine E. Squires, Kyle J. Gerber, et al. · Journal of Biological Chemistry · 14
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Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2
2019 · Kyle J. Gerber, Eric B. Dammer, et al. · Journal of Proteome Research · 20
Characterizing a Novel RGS14:MyosinV/VI Interaction in Brain
2019 · Carolina Montanez‐Miranda, Paul R. Evans, et al. · The FASEB Journal
14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gαi–AlF4− signaling complex and RGS14 nuclear localization
2018 · Kyle J. Gerber, Katherine E. Squires, et al. · Journal of Biological Chemistry · 16
Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease
2018 · Katherine E. Squires, Carolina Montañez-Miranda, et al. · Pharmacological Reviews · 71
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RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling
2018 · Paul R. Evans, Paula Parra-Bueno, et al. · eNeuro · 57
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner
2018 · Paul R. Evans, Kyle J. Gerber, et al. · Journal of Proteome Research · 27
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Direct visualization of interaction between calmodulin and connexin45
2017 · Juan Zou, Mani Salarian, et al. · Biochemical Journal · 23
Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus
2017 · Mary Rose Branch, John R. Hepler · PLoS ONE · 14
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Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain
2017 · Katherine E. Squires, Kyle J. Gerber, et al. · Brain Structure and Function · 28
RGS14 regulates the lifetime of G α ‐GTP signaling but does not prolong G βγ signaling following receptor activation in live cells
2016 · Nicole E. Brown, Nevin A. Lambert, et al. · Pharmacology Research & Perspectives · 14
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Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity
2015 · Kyle J. Gerber, Katherine E. Squires, et al. · Molecular Pharmacology · 118
Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)
2015 · Nicole E. Brown, Devrishi Goswami, et al. · Journal of Biological Chemistry · 24
Bioluminescence Resonance Energy Transfer to Detect Protein-Protein Interactions in Live Cells
2015 · Nicole E. Brown, Joe B. Blumer, et al. · Methods in molecular biology · 36
Regulator of G Protein Signaling 14
2015 · Paul R. Evans, Serena M. Dudek, et al. · Progress in molecular biology and translational science · 26
G protein coupled receptor signaling complexes in live cells
2014 · John R Hepler · Cellular Logistics · 10
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Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells
2014 · Sungho Ghil, Kelly L. McCoy, et al. · PLoS ONE · 27
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