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Mechanism of clinical resistance to echinocandin antifungal drugs

Funding type: research
Funder scheme: R01
Start date: 2007-06-18
End date: 2014-05-31
Investigator: DAVID S PERLIN
Institution: RBHS-NEW JERSEY MEDICAL SCHOOL
Funded outputs count: 45
Funder award ID: R01AI069397
OpenAlex ID: G8317494489
Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae
2015 · Petros Ioannou, Aggeliki Andrianaki, et al. · Antimicrobial Agents and Chemotherapy · 10
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Echinocandin Resistance in Candida
2015 · David S. Perlin · Clinical Infectious Diseases · 374
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Mechanisms of echinocandin antifungal drug resistance
2015 · David S. Perlin · Annals of the New York Academy of Sciences · 313
Update on Antifungal Drug Resistance
2015 · David S. Perlin, Erika Shor, et al. · Current Clinical Microbiology Reports · 173
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Coping with Stress and the Emergence of Multidrug Resistance in Fungi
2015 · Erika Shor, David S. Perlin · PLoS Pathogens · 71
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Echinocandin resistance
2014 · Maiken C. Arendrup, David S. Perlin · Current Opinion in Infectious Diseases · 299
Echinocandin Resistance, Susceptibility Testing and Prophylaxis: Implications for Patient Management
2014 · David S. Perlin · Drugs · 99
Target Enzyme Mutations Confer Differential Echinocandin Susceptibilities in Candida kefyr
2014 · Janet F. Staab, Dionysios Neofytos, et al. · Antimicrobial Agents and Chemotherapy · 17
Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance
2014 · Catiana Dudiuk, Soledad Gamarra, et al. · Journal of Clinical Microbiology · 51
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Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
2014 · Fernando César Bizerra, Cristina Jimenez-Ortigosa, et al. · Antimicrobial Agents and Chemotherapy · 63
Rapid Antifungal Susceptibility Testing by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Analysis
2013 · Antonietta Vella, Elena De Carolis, et al. · Journal of Clinical Microbiology · 124
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Isavuconazole Activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, Emerging Fungal Pathogens with Reduced Azole Susceptibility
2013 · K. Datta, P. Rhee, et al. · Journal of Clinical Microbiology · 42
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Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
2013 · Barbara D. Alexander, Melissa D. Johnson, et al. · Clinical Infectious Diseases · 780
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Evaluation of fungal-specific fluorescent labeled echinocandin probes as diagnostic adjuncts
2012 · Ayiasha Pratt, Guillermo Garcia-Effron, et al. · Medical Mycology · 19
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Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance
2012 · Santosh K. Katiyar, Ana Alastruey-Izquierdo, et al. · Antimicrobial Agents and Chemotherapy · 148
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Epidemiology and echinocandin susceptibility of Candida parapsilosis sensu lato species isolated from bloodstream infections at a Spanish university hospital
2012 · G. Garcia-Effron, E. Canton, et al. · Journal of Antimicrobial Chemotherapy · 41
Molecular mechanisms of cryptococcal meningitis
2012 · Tong-Bao Liu, David S. Perlin, et al. · Virulence · 131
The Proteomic Signature of Aspergillus fumigatus During Early Development
2011 · Steven E. Cagas, Mohit Raja Jain, et al. · Molecular & Cellular Proteomics · 41
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Assessment of Two New Molecular Methods for Identification of Candida parapsilosis Sensu Lato Species
2011 · Guillermo Garcia-Effron, Emilia Canton, et al. · Journal of Clinical Microbiology · 34
Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance
2011 · Ronen Ben-Ami, Guillermo Garcia-Effron, et al. · The Journal of Infectious Diseases · 163
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Disseminated Candidiasis Caused by Candida albicans with Amino Acid Substitutions in Fks1 at Position Ser645 Cannot Be Successfully Treated with Micafungin
2011 · J. L. Slater, S. J. Howard, et al. · Antimicrobial Agents and Chemotherapy · 52
Current Perspectives on Echinocandin Class Drugs
2011 · David S Perlin · Future Microbiology · 274
Two Major Inositol Transporters and Their Role in Cryptococcal Virulence
2011 · Yina Wang, Tong-bao Liu, et al. · Eukaryotic Cell · 38
Improved Detection of Candida sp. fks Hot Spot Mutants by Using the Method of the CLSI M27-A3 Document with the Addition of Bovine Serum Albumin
2011 · Guillermo Garcia-Effron, Steven Park, et al. · Antimicrobial Agents and Chemotherapy · 30
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Evaluation of CLSI M44-A2 Disk Diffusion and Associated Breakpoint Testing of Caspofungin and Micafungin Using a Well-Characterized Panel of Wild-Type and fks Hot Spot Mutant Candida Isolates
2011 · Maiken Cavling Arendrup, Steven Park, et al. · Antimicrobial Agents and Chemotherapy · 28
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