Get started
Award

Central Nervous System Tissue Organogenesis via Precise Growth Factor Tethering

Description: PUBLIC HEALTH RELEVANCE: The primary goal of this work is to understand and establish how a unique growth factor-biomaterial system can be used to deliver and direct neural stem cells to create central nervous system bridges to improve recovery from spinal cord injury. There is currently no available treatment for treating debilitating spinal cord injury and patients must live with decreased or absent sensory and motor function below the damaged region. This work will help us understand the treatment potential of this system and reveal new strategies to improve the quality of life for millions of patients living with spinal cord injuries.
Funding type: research
Funder scheme: R21
Start date: 2016-07-01
End date: 2019-06-30
Investigator: NIC D LEIPZIG
Institution: UNIVERSITY OF AKRON
Funded outputs count: 15
Funder award ID: R21NS096571
OpenAlex ID: G8317692891
Investigating Mechanisms of Subcutaneous Preconditioning Incubation for Neural Stem Cell Embedded Hydrogels
2022 · Mohammad Hamrangsekachaee, Hannah J. Baumann, et al. · ACS Applied Bio Materials · 7
PDF
Metabolomic and Signaling Programs Induced by Immobilized versus Soluble IFN γ in Neural Stem Cells
2020 · Hannah J. Baumann, Patricia Betonio, et al. · Bioconjugate Chemistry · 11
PDF
Softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content
2020 · Hannah J. Baumann, Gautam Mahajan, et al. · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 25
Covalently Immobilizing Interferon-γ Drives Filopodia Production through Specific Receptor–Ligand Interactions Independently of Canonical Downstream Signaling
2020 · Shaun M. Christie, Trevor R. Ham, et al. · Bioconjugate Chemistry · 6
PDF
Subcutaneous priming of protein-functionalized chitosan scaffolds improves function following spinal cord injury
2020 · Trevor R Ham, Dipak D Pukale, et al. · Materials Science and Engineering C · 29
pH-dependent RNA isolation from cells encapsulated in chitosan-based biomaterials
2020 · Mahmoud Farrag, Shahrzad Abri, et al. · International Journal of Biological Macromolecules · 16
Concurrent Delivery of Soluble and Immobilized Proteins to Recruit and Differentiate Neural Stem Cells
2019 · Trevor R. Ham, Dakotah G. Cox, et al. · Biomacromolecules · 6
Automated Gait Analysis Detects Improvements after Intracellular σ Peptide Administration in a Rat Hemisection Model of Spinal Cord Injury
2019 · Trevor R. Ham, Mahmoud Farrag, et al. · Annals of Biomedical Engineering · 15
Subcutaneous Maturation of Neural Stem Cell-Loaded Hydrogels Forms Region-Specific Neuroepithelium
2018 · Mahmoud Farrag, Nic D. Leipzig · Cells · 15
PDF
Evaluation of in situ gelling chitosan-PEG copolymer for use in the spinal cord
2018 · Ashley E Mohrman, Mahmoud Farrag, et al. · Journal of Biomaterials Applications · 22
The Open Source GAITOR Suite for Rodent Gait Analysis
2018 · Brittany Y. Jacobs, Emily H. Lakes, et al. · Scientific Reports · 49
PDF
Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels
2018 · Hang Li, Jukuan Zheng, et al. · Journal of Biomaterials Applications · 27
Biomaterial strategies for limiting the impact of secondary events following spinal cord injury
2017 · Trevor R Ham, Nic D Leipzig · Biomedical Materials · 41
Covalent growth factor tethering to direct neural stem cell differentiation and self-organization
2017 · Trevor R. Ham, Mahmoud Farrag, et al. · Acta Biomaterialia · 44
Year
Topic