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Quantitative Biology

Description: PUBLIC HEALTH RELEVANCE: The goal of the Quantitative Biology program is to train Ph.D. scientists who are well equipped to bring quantitative experimental, computational, and mathematical methods to bear on important problems in biomedical research. It is anticipated that the work of these scientists will lead to improvements in public health by advancing basic biomedical research in directions that are not readily accessible to scientists who lack interdisciplinary training.
Funding type: training
Funder scheme: T32
Start date: 2009-07-01
End date: 2019-08-31
Investigator: JEFF GELLES
Institution: BRANDEIS UNIVERSITY
Funded outputs count: 55
Funder award ID: T32EB009419
OpenAlex ID: G8545274368
An activity–resistance trade-off constrains enzyme evolution
2026 · Alexander W. Sarkis, Jens Laurids Sørensen, et al. · Proceedings of the National Academy of Sciences
The small RNA landscape is stable with age and resistant to loss of dFOXO signaling in Drosophila
2022 · Siobhan Gartland, Baosheng Zeng, et al. · PLoS ONE · 2
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TFIID Enables RNA Polymerase II Promoter-Proximal Pausing
2020 · Charli B. Fant, Cecilia B. Levandowski, et al. · Molecular Cell · 95
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A structural determinant of mycophenolic acid resistance in eukaryotic inosine 5′‐monophosphate dehydrogenases
2019 · Rebecca Freedman, Runhan Yu, et al. · Protein Science · 19
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Multimapping confounds ribosome profiling analysis: A case‐study of the Hsp90 molecular chaperone
2019 · Jackson C. Halpin, Radhika Jangi, et al. · Proteins Structure Function and Bioinformatics · 6
The Metastasis Suppressor Protein Nme1 Is a Concentration-Dependent Modulator of Ca2+/Calmodulin-Dependent Protein Kinase II
2019 · Leandro Royer, Kathryn Shangraw, et al. · Biochemistry · 1
Live cell monitoring of double strand breaks in S. cerevisiae
2019 · David P. Waterman, Felix Zhou, et al. · PLoS Genetics · 30
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Statistical properties of autonomous flows in 2D active nematics
2019 · Linnea M. Lemma, Stephen J. DeCamp, et al. · Soft Matter · 81
Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH
2018 · Jessica A. Haley, David Hampton, et al. · eLife · 41
Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase
2018 · Jacob D. Wirth, Jeffrey I. Boucher, et al. · Biochemistry · 18
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Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
2018 · Ricardo A. P. Pádua, Yizhi Sun, et al. · Nature Communications · 129
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TDP-43 misexpression causes defects in dendritic growth
2017 · Josiah J. Herzog, Mugdha Deshpande, et al. · Scientific Reports · 40
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Hsp90 Sensitivity to ADP Reveals Hidden Regulation Mechanisms
2017 · Jackson C. Halpin, Timothy O. Street · Journal of Molecular Biology · 13
The Limiting-Pool Mechanism Fails to Control the Size of Multiple Organelles
2017 · Lishibanya Mohapatra, Thibaut J. Lagny, et al. · Cell Systems · 49
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Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue
2017 · Larry E. Tetone, Larry J. Friedman, et al. · Proceedings of the National Academy of Sciences · 40
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Chromosome-refolding model of mating-type switching in yeast
2016 · Barış Avşaroğlu, Gabriel Bronk, et al. · Proceedings of the National Academy of Sciences · 13
Purification of Native Complexes for Structural Study Using a Tandem Affinity Tag Method
2016 · Clarisse van der Feltz, Daniel Pomeranz Krummel · Journal of Visualized Experiments · 3
The allosteric switching mechanism in bacteriophage MS2
2016 · Matthew R. Perkett, Dina T. Mirijanian, et al. · The Journal of Chemical Physics · 15
Exact Length Distribution of Filamentous Structures Assembled from a Finite Pool of Subunits
2016 · David Harbage, Jané Kondev · The Journal of Physical Chemistry B · 3
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Configurable NOR gate arrays from Belousov-Zhabotinsky micro-droplets
2016 · A.L. Wang, J.M. Gold, et al. · The European Physical Journal Special Topics · 34
Crowding Activates Heat Shock Protein 90
2016 · Jackson C. Halpin, Bin Huang, et al. · Journal of Biological Chemistry · 25
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An inexpensive programmable illumination microscope with active feedback
2016 · Nathan Tompkins, Seth Fraden · American Journal of Physics · 12
Instabilities, defects, and defect ordering in an overdamped active nematic
2016 · Elias Putzig, Gabriel S. Redner, et al. · Soft Matter · 79
Single-molecule visualization of a formin-capping protein ‘decision complex’ at the actin filament barbed end
2015 · Jeffrey P. Bombardier, Julian A. Eskin, et al. · Nature Communications · 105
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Learning dynamic control of body roll orientation
2015 · Vivekanand Pandey Vimal, James R. Lackner, et al. · Experimental Brain Research · 16
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