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C8717/A18245

Funded outputs count: 48
Funder award ID: C8717/A18245
OpenAlex ID: G856400422
KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9
2026 · Roman Belle, John-Paul Bukowski, et al. · Nature Chemistry · 2
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Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2‐Oxoglutarate Binding Mode and Conformation
2026 · Yihong Sun, Siddhant Dhingra, et al. · ChemBioChem
Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome
2025 · Cynthia X. Hou, Amelia Brasnett, et al. · Journal of Biological Chemistry · 3
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Profiling Inhibitor Scaffolds for the Cancer Target Jumonji‐C Domain‐Containing Protein 6
2025 · Thomas P. Corner, Eidarus Salah, et al. · ChemMedChem · 6
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Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates
2025 · Thomas P. Corner, Eidarus Salah, et al. · RSC Chemical Biology · 5
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JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships
2024 · Joanna Bonnici, Razanne Oueini, et al. · Communications Biology · 8
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Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes
2024 · Giorgia Fiorini, Stephen A. Marshall, et al. · Scientific Reports · 6
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Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat
2024 · Thomas P. Corner, Eidarus Salah, et al. · ChemMedChem · 7
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Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7
2024 · Nurgül Bilgin, Anthony Tumber, et al. · Protein Science · 2
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The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
2024 · Hannah Lawson, James P. Holt-Martyn, et al. · Nature Cancer · 42
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Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
2024 · Tobias John, Nadia Saffoon, et al. · Chemical Science · 6
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Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation
2024 · Gayatri, Lennart Brewitz, et al. · Chemical Science · 11
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Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein
2023 · H. T. Henry Chan, Lennart Brewitz, et al. · RSC Chemical Biology · 10
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Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
2023 · Lennart Brewitz, H.T. Henry Chan, et al. · Bioorganic & Medicinal Chemistry · 4
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5
2023 · Lennart Brewitz, Yu Nakashima, et al. · Journal of Medicinal Chemistry · 13
Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2
2023 · William D. Figg, Giorgia Fiorini, et al. · Proteins Structure Function and Bioinformatics · 14
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Data from JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer
2023 · Alec Paschalis, Jonathan Welti, et al.
Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors
2023 · Shuang Liu, Martine Abboud, et al. · Journal of Medicinal Chemistry · 18
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Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
2023 · Lennart Brewitz, Leo Dumjahn, et al. · Journal of Medicinal Chemistry · 71
The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation
2023 · Joanna Bonnici, Razanne Oueini, et al. · FEBS Letters · 17
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Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
2023 · Xiao Liu, Raphael Reinbold, et al. · Journal of Biological Chemistry · 9
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5
2023 · Anthony Tumber, Eidarus Salah, et al. · RSC Chemical Biology · 16
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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors
2022 · Raphael Reinbold, Ingvild C. Hvinden, et al. · Nature Communications · 62
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Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6
2022 · Matthew E. Cockman, Yoichiro Sugimoto, et al. · Proceedings of the National Academy of Sciences · 35
Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation
2022 · Lennart Brewitz, Bruce C. Onisko, et al. · Journal of Biological Chemistry · 18
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