Award

Deer Mice as Tools for Infectious Disease Research

Description: Hantaviruses can cause fatal diseases in humans, including hantavirus cardiopulmonary syndrome (HCPS). Sin Nombre virus, is hosted by the deer mouse (Peromyscus maniculatus) and causes most HCPS cases in North American, while Andes virus, hosted by the long-tailed pygmy rice rat (Oligoryzomys longicaudatus), causes most HCPS cases in South America. This project will examine how deer mice fail to clear Sin Nombre virus but clear Andes virus.

Funder: National Institute of Allergy and Infectious Diseases

Funding type: research

Funder scheme: R15

Start date: 2006-07-01

End date: 2017-06-30

Investigator: ANN HAWKINSON

Institution: UNIVERSITY OF NORTHERN COLORADO

Topic: Viral Infections and Vectors

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

Funded outputs count: 11

Funder award ID: R15AI054461

OpenAlex ID: G8564101815

Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters

2019 · Tony Schountz, Corey Campbell, et al. · Viruses · 64

Maporal Hantavirus Causes Mild Pathology in Deer Mice (Peromyscus maniculatus)

2016 · Amanda McGuire, Kaitlyn Miedema, et al. · Viruses · 17

Transcriptome Markers of Viral Persistence in Naturally-Infected Andes Virus (Bunyaviridae) Seropositive Long-Tailed Pygmy Rice Rats

2015 · Corey L. Campbell, Fernando Torres-Perez, et al. · PLoS ONE · 11

Differential Lymphocyte and Antibody Responses in Deer Mice Infected with Sin Nombre Hantavirus or Andes Hantavirus

2014 · Tony Schountz, Sandra Quackenbush, et al. · Journal of Virology · 23

Rapid Enzyme-Linked Immunosorbent Assay for the Detection of Hantavirus-Specific Antibodies in Divergent Small Mammals

2014 · Karla Cautivo, Tony Schountz, et al. · Viruses · 10

Hantavirus Immunology of Rodent Reservoirs: Current Status and Future Directions

2014 · Tony Schountz, Joseph Prescott · Viruses · 64

Kinetics of Immune Responses in Deer Mice Experimentally Infected with Sin Nombre Virus

2012 · Tony Schountz, Mariana Acuña-Retamar, et al. · Journal of Virology · 44

Genomic organization and phylogenetic utility of deer mouse (Peromyscus maniculatus) lymphotoxin-alpha and lymphotoxin-beta

2008 · Tiffany Richens, Aparna D~N Palmer, et al. · BMC Immunology

Rapid Field Immunoassay for Detecting Antibody to Sin Nombre Virus in Deer Mice

2007 · Tony Schountz, Charles H. Calisher, et al. · Emerging infectious diseases · 32

Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus

2007 · Tony Schountz, Joseph Prescott, et al. · Proceedings of the National Academy of Sciences · 107

Profiling helper T cell subset gene expression in deer mice

2006 · Lauren Oko, Bethany Aduddell-Swope, et al. · BMC Immunology · 13