Menin/MLL promotes cell survival in the setting of EGFR inhibition
Description: PUBLIC HEALTH RELEVANCE: Epidermal growth factor receptor (EGFR) signaling is important in colonic epithelial homeostasis, injury repair, and colon cancer pathogenesis. Preliminary experiments showed that in colonic epithelial derived cells, the epigenetic complex menin/MLL is critical for cell survival in the setting of EGFR inhibition. We propose to (1) define the mechanism through which menin/MLL promotes cell survival in the setting of EGFR inhibition and (2) determine if menin/MLL inhibition in vivo can improve EGFR-directed therapy in colon cancer, and inhibit the development of colitis and colitis associated cancer.
Funding type: career_development
Funder scheme: K08
Start date: 2015-07-22
End date: 2020-06-30
Investigator: BRYSON WILLIAM KATONA
Institution: UNIVERSITY OF PENNSYLVANIA
Funded outputs count: 20
Funder award ID: K08DK106489
OpenAlex ID: G8635526179