Cerebral Artery Alpha1 Adrenergic and PKC Regulatory Mechanisms
Description: PUBLIC HEALTH RELEVANCE: At every stage of life, regulation of blood flow to the brain is of critical importance. Many infants, particularly those that are premature, suffer from dysregulation of cerebrovascular blood flow with intracerebral hemorrhage and severe long-term neurological sequelae. Scientifically, the proposed studies will augment our understanding of basic mechanisms whereby blood vessels to the brain of fetus, premature newborn, and adult change with developmental maturation. From a clinical standpoint, these studies relate to important problems such as the regulation of brain blood flow and metabolism in fetus and newborn infant, their responses to hypoxia as occurs in women who smoke, as well as those who are anemic, or who have heart or lung disease, and the mechanisms of maternal stress and prenatal "programming".
Funding type: research
Funder scheme: R01
Start date: 1978-02-01
End date: 2017-01-31
Investigator: RAVI GOYAL
Institution: LOMA LINDA UNIVERSITY
Field: Medicine
Domain: Health Sciences
Funded outputs count: 86
Funder award ID: R01HD003807
OpenAlex ID: G874190830