Role of de Novo Synthesis of Sphingolipids in Aneuploid Cells
Description: Project Narrative Aneuploidy, which represents a cellular state of having an abnormal number of chromosomes, is associated with human diseases including intellectual disability, neurodegenerative diseases and cancer. Our preliminary results indicate that lipid metabolism is altered by aneuploidy; we therefore propose to identify the molecular mechanisms underlying this effect. Deciphering the molecular mechanism that alters lipid synthesis in aneuploid cells will significantly contribute to our understanding how normal cells regulate the levels of, and respond to changes in lipid composition potentially leading to a better rationale for utilizing drugs that target sphingolipid metabolism in the clinic.
Funding type: research
Funder scheme: R01
Start date: 2017-02-01
End date: 2022-12-31
Investigator: EDUARDO MARTIN TORRES
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Funded outputs count: 6
Funder award ID: R01GM118481
OpenAlex ID: G8754635448