Oncogenic Events in Thyroid Neoplasia
Description: PUBLIC HEALTH RELEVANCE: We discovered that loss-of-function of NF2, the gene encoding for Merlin, and mutations of the translation initiation factor EIF1AX, are common events in poorly differentiated thyroid cancers, and are strongly associated with RAS mutations. We aim to understand how merlin cooperates with RAS to transform thyroid cells, based on evidence that this interaction is largely mediated by Hippo signaling to YAP, which enhances RAS gene expression and signaling and modulates responses to therapies targeting RAS itself or its downstream effectors. The functional consequences of the mutations of EIF1AX on translational regulation are unknown and will be studied as isolated events and in the context of RAS mutations.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 1996-12-21
End date: 2021-12-31
Investigator: JAMES A FAGIN
Institution: SLOAN-KETTERING INST CAN RESEARCH
Subfield: Cell Biology
Domain: Life Sciences
Funded outputs count: 68
Funder award ID: R01CA072597
OpenAlex ID: G8756996438