Study for the best matrix environment for neurogenesis in the aged subventricular zone
Description: The purpose of this study is to show a sugar chain modification that rescues the attenuation of neurogenesis signals due to aging, and to explore new therapeutic methods that complement cell and gene therapy. We have so far verified that the expression pattern and sugar chain modification of heparan sulfate proteoglycan (HSPG) are changed in mouse aging SVZ, and the fate control of stem cells is changed. We reported a decrease in proteoglycan groups and an increase in extracellular sulfatase Sulf1 and 2 using them as substrates. Sulf1 / 2, which modifies the 6O-sulfatio of the HS chain to desulfurize extracellularly, regulates the binding of heparin-affinity factors such as GDNF, HGF, and FGF to HSPG extracellularly, and cleverly signals the signals of these factors. However, the details of individual life events are still unknown. Therefore, in this study, we use Sulf1 / 2 DKO to clarify the direct involvement of Sulfur and neurogenesis and the related molecular mechanism.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Eri Arikawa-Hirasawa
Institution: Juntendo University
Funded outputs count: 9
Funder award ID: 18K07535
OpenAlex ID: G8765645992