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Inhibition of CDC25B phosphatase by targeting protein-protein interactions

Description: PUBLIC HEALTH RELEVANCE: In the proposed research we will identify valuable small molecule inhibitors of CDC25B phosphatase by targeting protein-protein interaction with CDK2/CyclinA. Ultimately, this research might lead to novel cell-cycle inhibitors and anti-cancer agents.

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2013-12-01

End date: 2017-11-30

Investigator: TOMASZ CIERPICKI

Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 6

Funder award ID: R01CA181185

OpenAlex ID: G8779647479

Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules

2017 · Wiktoria Jedwabny, Szymon Kłossowski, et al. · MedChemComm · 11

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

2016 · Felicia Gray, Hyo Je Cho, et al. · Nature Communications · 90

H3K36 Methyltransferases as Cancer Drug Targets: Rationale and Perspectives for Inhibitor Development

2016 · David S Rogawski, Jolanta Grembecka, et al. · Future Medicinal Chemistry · 47

Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes

2015 · Jonathan Pollock, Dmitry Borkin, et al. · Journal of Medicinal Chemistry · 107

Inhibition of CDC25B Phosphatase Through Disruption of Protein–Protein Interaction

2014 · George Lund, Sergii Dudkin, et al. · ACS Chemical Biology · 36

Solution NMR studies reveal no global flexibility in the catalytic domain of CDC25B

2014 · George Lund, Tomasz Cierpicki · Proteins Structure Function and Bioinformatics · 6