Methods and approaches to expand the pharmacological toolset
Description: Project Narrative Our laboratory uses high throughput chemical screening combined with modern target identification techniques to identify novel small molecules with physiological activity. This approach results in pharmacologically privileged mechanistic information and often the chemical starting points for drug development campaigns. This work will principally focus on three key areas: identifying compounds to promote regenerative organ repair, developing small molecule activators of transcriptional stress responses, and advancing methodology to identify small molecules with novel reactivity and/or biological activity.
Funding type: research
Funder scheme: R35
Start date: 2022-08-15
End date: 2027-06-30
Investigator: MICHAEL J BOLLONG
Institution: SCRIPPS RESEARCH INSTITUTE, THE
Funded outputs count: 25
Funder award ID: R35GM146865
OpenAlex ID: G9000856413