A subunit Cryptococcus vaccine
Description: Project Narrative Cryptococcosis, due to infection by the encapsulated yeasts C. neoformans and C. gattii, is the most common etiological agent of culture-positive meningitis. Nearly 200,000 people, most of whom are HIV-infected, die from this disease annually. The proposed research addresses a global public health need for a cryptococcal vaccine by using carefully designed mouse and human studies to develop a subunit multiantigen vaccine suitable for eventual human testing.
Funding type: research
Funder scheme: R01
Start date: 2022-07-21
End date: 2027-06-30
Investigator: STUART MICHAEL LEVITZ
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Funded outputs count: 18
Funder award ID: R01AI172154
OpenAlex ID: G9000856445