Role of Sam68 in Proinflammatory Signaling
Description: Project Narrative Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) affecting over 1 million people in the United States and its incidence is increasing. Our study addresses the challenge of identifying preclinical human IBD mechanisms and focuses on the role of the protein Sam68 as a critical mediator of tumor necrosis factor (TNF) and toll like receptor (TLR) induced inflammation in UC. Successful completion of this study will reveal Sam68 as a key player in UC pathogenesis and lead to the design of novel therapeutics targeting Sam68 for chronic inflammatory conditions.
Funding type: research
Funder scheme: R01
Start date: 2022-04-01
End date: 2027-02-28
Investigator: PARAMESWARAN RAMAKRISHNAN
Institution: CASE WESTERN RESERVE UNIVERSITY
Funded outputs count: 14
Funder award ID: R01DK128463
OpenAlex ID: G9000856463