Spatial and temporal control of Rho family GTPases
Description: This proposal focuses on dissecting of the molecular mechanisms involved in the control of cell division, cell polarization, and morphogenesis. These simultaneously interrelated and functionally distinct processes are controlled by small GTPases, switch like proteins that primarily act at cell membranes to remodel cellular physiology. We propose to study the role of several small GTPases during these processes in intact model organisms, including the nematode C. elegans and the fruit fly, Drosophila using a combination of live cell imaging, classical genetics, and optogenetics.
Funding type: research
Funder scheme: R35
Start date: 2018-08-01
End date: 2028-07-31
Investigator: MICHAEL A. GLOTZER
Institution: UNIVERSITY OF CHICAGO
Funded outputs count: 12
Funder award ID: R35GM127091
OpenAlex ID: G9000856489