Pharmacogenetics of the Response to GLP-1 in Mexican-Americans with Prediabetes
Description: PROJECT NARRATIVE This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss, cardiovascular risk reduction, and renal protection. Newly discovered mechanisms will illuminate causal links between disease genotype and phenotype, which may ultimately guide personalized therapeutic approaches for type 2 diabetes, prediabetes, obesity, cardiovascular disease, renal disease, and other related diseases.
Funding type: research
Funder scheme: R01
Start date: 2021-07-09
End date: 2027-04-30
Investigator: ABSALON DENNIS GUTIERREZ
Institution: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
Funded outputs count: 7
Funder award ID: R01DK127084
OpenAlex ID: G9000910403