Concept

Endothelin 1

OpenAlex ID: C149601957

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 · Masashi Yanagisawa, Hiroki Kurihara, et al. · Nature · 10,724

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Frontotemporal lobar degeneration

1998 · D. Neary, J. S. Snowden, et al. · Neurology · 5,087

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 · Takeshi Sakurai, Masashi Yanagisawa, et al. · Nature · 2,420

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Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 · Adel Giaid, Masashi Yanagisawa, et al. · New England Journal of Medicine · 1,860

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Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 · G de Nucci, R Thomas, et al. · Proceedings of the National Academy of Sciences · 1,407

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 · C Boulanger, T F Lüscher · Journal of Clinical Investigation · 1,043

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Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 · Duncan J. Stewart, Robert D. Levy, et al. · Annals of Internal Medicine · 986

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

1994 · Yukiko Kurihara, Hiroki Kurihara, et al. · Nature · 982

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 · Amir Lerman, Brooks S. Edwards, et al. · New England Journal of Medicine · 955

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 · Dong Xu, Noriaki Emoto, et al. · Cell · 927

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 · Masaki Ihara, Kazuhito Noguchi, et al. · Life Sciences · 873

Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction

2017 · Chang Chen, Jin-Lai Gao, et al. · Cellular Physiology and Biochemistry · 786

Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.

1998 · O Hernández-Perera, D Pérez-Sala, et al. · Journal of Clinical Investigation · 761

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 · Issei Komuro, Hiroki Kurihara, et al. · FEBS Letters · 727

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 · S Kourembanas, P A Marsden, et al. · Journal of Clinical Investigation · 685

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C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells

2003 · Sridevi Devaraj, Dan Yan Xu, et al. · Circulation · 644

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 · R J Cody, G J Haas, et al. · Circulation · 643

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 · H E Shubeita, P M McDonough, et al. · Journal of Biological Chemistry · 641

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 · O.F. Wagner, G Christ, et al. · Journal of Biological Chemistry · 637

Clearance of Circulating Endothelin-1 by ETB Receptors in Rats

1994 · T. Fukuroda, T. Fujikawa, et al. · Biochemical and Biophysical Research Communications · 633

Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein

2002 · Subodh Verma, Shu-Hong Li, et al. · Circulation · 628

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

1996 · Satoshi Sakai, Takashi Miyauchi, et al. · Nature · 626

Review and update of mutations causing Waardenburg syndrome

2010 · Véronique Pingault, Dorothée Ente, et al. · Human Mutation · 616

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Endothelins and Endothelin Receptor Antagonists

2000 · Thomas F. Lüscher, Matthias Barton · Circulation · 604

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Contribution of endogenous generation of endothelin-1 to basal vascular tone

1994 · W HAYNES · The Lancet · 592

Works count: 18,400

Citation count: 451,500