Concept

Semisynthesis

OpenAlex ID: C162776295

Expressed protein ligation: A general method for protein engineering

1998 · Tom W. Muir, Dolan Sondhi, et al. · Proceedings of the National Academy of Sciences · 1,201

Total synthesis of taxol

1994 · K. C. Nicolaou, Z. Yang, et al. · Nature · 1,122

Natural products as leads to anticancer drugs

2007 · M. Gordaliza · Clinical & Translational Oncology · 714

Semisynthesis of Proteins by Expressed Protein Ligation

2003 · Tom W. Muir · Annual Review of Biochemistry · 699

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

2017 · Lindsay M. Repka, Jonathan R. Chekan, et al. · Chemical Reviews · 555

Cobalt proteins

1999 · Michihiko Kobayashi, Sakayu Shimizu · European Journal of Biochemistry · 452

Semisynthesis of cytotoxic proteins using a modified protein splicing element

1998 · Thomas C. Evans, Jack Benner, et al. · Protein Science · 372

A platform for the discovery of new macrolide antibiotics

2016 · Ian B. Seiple, Ziyang Zhang, et al. · Nature · 359

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

1992 · Iwao Ojima, Ivan Habus, et al. · Tetrahedron · 325

Recent Developments in the Field of β‐Lactam Antibiotics

1985 · Walter Dürckheimer, Jürgen Blumbach, et al. · Angewandte Chemie International Edition in English · 304

A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

2005 · Mark G. Charest, Christian D. Lerner, et al. · Science · 300

Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

2008 · Martin E. Kolewe, Vishal Gaurav, et al. · Molecular Pharmaceutics · 296

Extending Synthetic Access to Proteins with a Removable Acyl Transfer Auxiliary

2002 · John Offer, C. N. C. Boddy, et al. · Journal of the American Chemical Society · 281

Taxol: biosynthesis, molecular genetics, and biotechnological applications

2001 · Jennewein S., Croteau R. · Applied Microbiology and Biotechnology · 259

Nineteen-step total synthesis of (+)-phorbol

2016 · Shuhei Kawamura, Hang Chu, et al. · Nature · 251

Chemoenzymatic Semisynthesis of Proteins

2019 · Robert E. Thompson, Tom W. Muir · Chemical Reviews · 250

Insulin structure and function

2007 · John P. Mayer, Faming Zhang, et al. · Biopolymers · 248

Site-Specific Protein Immobilization by Staudinger Ligation

2003 · Matthew B. Soellner, Kimberly A. Dickson, et al. · Journal of the American Chemical Society · 236

A Continuous‐Flow Process for the Synthesis of Artemisinin

2013 · Daniel Kopetzki, François Lévesque, et al. · Chemistry - A European Journal · 223

Oxidation in organic chemistry part A

1969 · John O. Edwards · Journal of the Franklin Institute · 218

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

2012 · Mary Katherine Tarrant, Hee-Sool Rho, et al. · Nature Chemical Biology · 191

Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α- O -benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli

2000 · Kevin Walker, Rodney Croteau · Proceedings of the National Academy of Sciences · 187

Taxane Anticancer Agents: Basic Science and Current Status

1994 · Gunda I. Georg1, Thomas T. Chen2, et al. · ACS symposium series · 187

Toward a Biosynthetic Route to Sclareol and Amber Odorants

2012 · Michel Schalk, Laurence Pastore, et al. · Journal of the American Chemical Society · 183

Semisynthesis and Folding of the Potassium Channel KcsA

2002 · Francis I. Valiyaveetil, Roderick MacKinnon, et al. · Journal of the American Chemical Society · 174

Works count: 1,992

Citation count: 35,940