Concept

Granzyme

OpenAlex ID: C183193105

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

2019 · Weimin Wang, Michael Green, et al. · Nature · 2,912

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 · Nancy A. Thornberry, Thomas A. Rano, et al. · Journal of Biological Chemistry · 2,089

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

2007 · Hania Kebir, Katharina Kreymborg, et al. · Nature Medicine · 1,811

Perforin and granzymes: function, dysfunction and human pathology

2015 · Ilia Voskoboinik, James C. Whisstock, et al. · Nature reviews. Immunology · 1,410

Functional significance of the perforin/granzyme cell death pathway

2002 · Joseph A. Trapani, Mark J. Smyth · Nature reviews. Immunology · 1,347

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

2020 · Zhiwei Zhou, Huabin He, et al. · Science · 1,321

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

2020 · Rong Tang, Jin Xu, et al. · Journal of Hematology & Oncology · 1,292

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CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

1998 · Y Naito, K Saito, et al. · PubMed · 1,182

Lymphocyte-Mediated Cytotoxicity

2002 · John H. Russell, Timothy J. Ley · Annual Review of Immunology · 1,153

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 · Xuefang Cao, Sheng F. Cai, et al. · Immunity · 1,117

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Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 · William J. Grossman, James W. Verbsky, et al. · Immunity · 1,104

An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

1998 · Steffen Stenger, Dennis A. Hanson, et al. · Science · 1,086

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

2013 · Jochem H Bernink, Charlotte P Peters, et al. · Nature Immunology · 1,054

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells

2010 · Mathilde Dusseaux, Emmanuel Martin, et al. · Blood · 1,045

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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

2003 · Erika L. Pearce, Alan C. Mullen, et al. · Science · 1,031

Hsp27 negatively regulates cell death by interacting with cytochrome c

2000 · Jean-Marie Bruey, Cécile Ducasse, et al. · Nature Cell Biology · 1,006

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

2003 · Jérôme Feldmann, Isabelle Callebaut, et al. · Cell · 946

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Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

2008 · Wen-Hung Chung, Shuen-Iu Hung, et al. · Nature Medicine · 856

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

2003 · Judy Lieberman · Nature reviews. Immunology · 832

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 · Jonathan W. Heusel, Robin L. Wesselschmidt, et al. · Cell · 820

Activation of NK cell cytotoxicity

2004 · Mark J. Smyth, Erika Cretney, et al. · Molecular Immunology · 745

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 · T Fernandes-Alnemri, R C Armstrong, et al. · Proceedings of the National Academy of Sciences · 732

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

2008 · Dipanjan Chowdhury, Judy Lieberman · Annual Review of Immunology · 728

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 · Alison J. Darmon, Donald W. Nicholson, et al. · Nature · 720

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 · P J Peters, J Borst, et al. · The Journal of Experimental Medicine · 718

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Works count: 6,614

Citation count: 248,500