Concept

Complementarity determining region

OpenAlex ID: C85630698

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936

2003 · J J M van Dongen, A W Langerak, et al. · Leukemia · 3,066

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1998 · Peter D. Kwong, Richard Wyatt, et al. · Nature · 3,038

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1986 · Peter T. Jones, Paul H. Dear, et al. · Nature · 1,451

An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody Complementarity

1970 · Tai Te Wu, Elvin A. Kabat · The Journal of Experimental Medicine · 1,348

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An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 · K. Christopher Garcia, Massimo Degano, et al. · Science · 1,304

Shape Complementarity at Protein/Protein Interfaces

1993 · Michael C. Lawrence, Peter M. Colman · Journal of Molecular Biology · 1,238

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

1991 · C F Barbas, A S Kang, et al. · Proceedings of the National Academy of Sciences · 1,201

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 · A. G. Amit, R. A. Mariuzza, et al. · Science · 1,185

Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells

2009 · Harlan S. Robins, Paulo V. Campregher, et al. · Blood · 1,141

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Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library

1996 · Tristan J. Vaughan, Andrew J. Williams, et al. · Nature Biotechnology · 1,045

Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

2001 · Erica Ollmann Saphire, Paul W. H. I. Parren, et al. · Science · 960

"Diabodies": small bivalent and bispecific antibody fragments.

1993 · P Holliger, T Prospero, et al. · Proceedings of the National Academy of Sciences · 883

Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

2003 · Daniel A. Calarese, Christopher N. Scanlan, et al. · Science · 789

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. Wilson

2000 · Achim Knappik, Liming Ge, et al. · Journal of Molecular Biology · 738

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

2014 · Nicole A. Doria-Rose, Chaim A. Schramm, et al. · Nature · 718

SAbDab: the structural antibody database

2013 · James Dunbar, Konrad Krawczyk, et al. · Nucleic Acids Research · 708

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

2011 · Robert Pejchal, Katie J. Doores, et al. · Science · 707

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

2013 · Dmitry Lyumkis, Jean-Philippe Julien, et al. · Science · 690

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 · K. Christopher Garcia, Massimo Degano, et al. · Science · 683

Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain

1997 · Karin Nord, Elin Gunneriusson, et al. · Nature Biotechnology · 676

A humanized antibody that binds to the interleukin 2 receptor.

1989 · C Queen, W P Schneider, et al. · Proceedings of the National Academy of Sciences · 633

The outline structure of the T‐cell alpha beta receptor.

1988 · C. Chothia, D. R. Boswell, et al. · The EMBO Journal · 618

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Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

2017 · Peter Bannas, Julia Hambach, et al. · Frontiers in Immunology · 608

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Escherichia coli Secretion of an Active Chimeric Antibody Fragment

1988 · Marc Better, C. Paul Chang, et al. · Science · 588

Phosphocholine binding immunoglobulin Fab McPC603

1986 · Yoshinori Satow, Gerson H. Cohen, et al. · Journal of Molecular Biology · 572

Works count: 3,690

Citation count: 170,900