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Synlogic (United States)
Homepage:
synlogictx.com
ROR:
019hezp12
OpenAlex ID:
I4210100181
Persister formation in Staphylococcus aureus is associated with ATP depletion
2016
·
Brian P. Conlon
, Sarah E. Rowe
, et al.
·
Nature Microbiology
·
672
Metabolic modulation of tumours with engineered bacteria for immunotherapy
2021
·
Fernando P. Canale
, Camilla Basso
, et al.
·
Nature
·
609
Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria
2018
·
Vincent M Isabella
, Binh N Ha
, et al.
·
Nature Biotechnology
·
602
Developing a new class of engineered live bacterial therapeutics to treat human diseases
2020
·
Mark R. Charbonneau
, Vincent M. Isabella
, et al.
·
Nature Communications
·
514
PDF
Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
2020
·
Daniel S. Leventhal
, Anna Sokolovska
, et al.
·
Nature Communications
·
453
PDF
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
2019
·
Caroline B. Kurtz
, Yves A. Millet
, et al.
·
Science Translational Medicine
·
397
Engineering living therapeutics with synthetic biology
2021
·
Andres Cubillos-Ruiz
, Tingxi Guo
, et al.
·
Nature Reviews Drug Discovery
·
356
Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation
2020
·
Jamie Bates
, Archana Vijayakumar
, et al.
·
Journal of Hepatology
·
228
The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls
2019
·
Jonna Jalanka
, Giles Major
, et al.
·
International Journal of Molecular Sciences
·
216
PDF
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
2023
·
Liliana M. Sanmarco
, Joseph M. Rone
, et al.
·
Nature
·
193
PDF
Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
2023
·
Jason J. Luke
, Sarina A. Piha-Paul
, et al.
·
Clinical Cancer Research
·
173
PDF
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study
2021
·
Marja K. Puurunen
, Jerry Vockley
, et al.
·
Nature Metabolism
·
170
Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering
2021
·
Kristin J. Adolfsen
, Isolde Callihan
, et al.
·
Nature Communications
·
99
PDF
Challenges in IBD Research: Environmental Triggers
2019
·
Shuk-Mei Ho
, James D Lewis
, et al.
·
Inflammatory Bowel Diseases
·
94
PDF
Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial
2023
·
Jerry Vockley
, Neal Sondheimer
, et al.
·
Nature Metabolism
·
86
Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
2021
·
M. Tyler Nelson
, Mark R. Charbonneau
, et al.
·
Nature Communications
·
78
PDF
Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)
2017
·
Birgit Schoeberl
, Art Kudla
, et al.
·
npj Systems Biology and Applications
·
73
PDF
Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa
2015
·
Vincent M. Isabella
, Arthur J. Campbell
, et al.
·
Chemistry & Biology
·
61
PDF
An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria
2022
·
David Lubkowicz
, Nicholas G Horvath
, et al.
·
Molecular Systems Biology
·
55
Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice
2019
·
Jasmohan S. Bajaj
, Patricia Pringle Bloom
, et al.
·
The American Journal of Gastroenterology
·
49
Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates
2017
·
Caroline Kurtz
, William S. Denney
, et al.
·
Clinical and Translational Science
·
43
PDF
The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers
2024
·
Mylène Perreault
, Jillian Means
, et al.
·
Cell Host & Microbe
·
36
Engineered bacteria producing aryl‐hydrocarbon receptor agonists protect against ethanol‐induced liver disease in mice
2023
·
Tetsuya Kouno
, Suling Zeng
, et al.
·
Alcoholism Clinical and Experimental Research
·
36
PDF
Complications of the Low Phenylalanine Diet for Patients with Phenylketonuria and the Benefits of Increased Natural Protein
2022
·
Nicole McWhorter
, Mesaki K. Ndugga-Kabuye
, et al.
·
Nutrients
·
33
PDF
Development of synthetic biotics as treatment for human diseases
2022
·
Aoife M Brennan
·
Synthetic Biology
·
33
PDF
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Works count:
76
Citation count:
37,680
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