Reaction Biology Corporation (United States)

Child institution: Reaction Biology (Germany)

ROR: 01ada6a49

OpenAlex ID: I4210103473

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

2011 · Theonie Anastassiadis, Sean W Deacon, et al. · Nature Biotechnology · 893

Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors

2014 · R. S. K. Vijayan, Peng He, et al. · Journal of Medicinal Chemistry · 245

The challenge of selecting protein kinase assays for lead discovery optimization

2008 · Haiching Ma, Sean Deacon, et al. · Expert Opinion on Drug Discovery · 197

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor

2016 · Jack Singer, Suliman Al-Fayoumi, et al. · Journal of Experimental Pharmacology · 128

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Necroptosis blockade prevents lung injury in severe influenza

2024 · Avishekh Gautam, David F. Boyd, et al. · Nature · 119

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Identification of Histone Deacetylase Inhibitors with Benzoylhydrazide Scaffold that Selectively Inhibit Class I Histone Deacetylases

2015 · Yunfei Wang, Ryan L. Stowe, et al. · Chemistry & Biology · 114

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Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents

2013 · Heng Yang, Christie E. Pinello, et al. · Molecular Cancer Therapeutics · 104

Assay Development for Histone Methyltransferases

2013 · Kurumi Y. Horiuchi, Mia M. Eason, et al. · Assay and Drug Development Technologies · 80

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

2018 · Nathan P. Coussens, Stephen C. Kales, et al. · Journal of Biological Chemistry · 74

Chemical microarray: a new tool for drug screening and discovery

2006 · Haiching Ma, Kurumi Y. Horiuchi · Drug Discovery Today · 73

Protein kinase profiling assays: a technology review

2015 · Yuren Wang, Haiching Ma · Drug Discovery Today Technologies · 65

Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

2017 · Fei Yi, Jia Guo, et al. · Journal of Virology · 45

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Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases

2016 · Krisna C. Duong-Ly, Karthik Devarajan, et al. · Cell Reports · 42

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Nanoliter Homogenous Ultra-High Throughput Screening Microarray for Lead Discoveries and IC 50 Profiling

2005 · Haiching Ma, Kurumi Y. Horiuchi, et al. · Assay and Drug Development Technologies · 41

Microarrays for the Functional Analysis of the Chemical-Kinase Interactome

2006 · Kurumi Y. Horiuchi, Yuan Wang, et al. · SLAS DISCOVERY · 38

Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK

2013 · Harina Vin, Grace Ching, et al. · Molecular Cancer Therapeutics · 33

Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

2020 · Yangbo Feng, HaJeung Park, et al. · ACS Medicinal Chemistry Letters · 32

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

2017 · Yuren Wang, Jason Wallach, et al. · Drug Design Development and Therapy · 32

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N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors

2021 · Yangbo Feng, HaJeung Park, et al. · ACS Medicinal Chemistry Letters · 25

Functional validation of DvABCB1 as a receptor of Cry3 toxins in western corn rootworm, Diabrotica virgifera virgifera

2020 · Xiping Niu, Adane Kassa, et al. · Scientific Reports · 24

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PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits

2020 · Feng Yi, Nirvan Rouzbeh, et al. · Neuropharmacology · 23

Methylene Blue Is a Nonspecific Protein–Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19

2022 · Sung-Ting Chuang, Henrietta Papp, et al. · Pharmaceuticals · 20

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Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET

2016 · Luke W. Koblan, Dennis L. Buckley, et al. · ChemMedChem · 20

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors

2014 · Mark E. McDonnell, Haiyan Bian, et al. · Bioorganic & Medicinal Chemistry Letters · 20

A Highly Selective Dual Insulin Receptor (IR)/Insulin-like Growth Factor 1 Receptor (IGF-1R) Inhibitor Derived from an Extracellular Signal-regulated Kinase (ERK) Inhibitor

2013 · Theonie Anastassiadis, Krisna C. Duong-Ly, et al. · Journal of Biological Chemistry · 20

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Works count: 102

Citation count: 8,224