Keyword

ABCA1

Description: ABCA1 is a gene encoding a membrane transporter involved in cholesterol and phospholipid export, studied in lipid metabolism and human disease.

Primary topic: Cholesterol and Lipid Metabolism (49%)

Wikidata ID: wiki/Q286987

OpenAlex ID: keywords/abca1

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 · Ajay Chawla, William A. Boisvert, et al. · Molecular Cell · 1,346

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MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

2010 · Katey J. Rayner, Yajaira Suárez, et al. · Science · 1,263

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

2001 · Giulia Chinetti, Sophie Lestavel, et al. · Nature Medicine · 1,168

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

2009 · Elmar W. Tobi, L.H. Lumey, et al. · Human Molecular Genetics · 1,157

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Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

2004 · Jonathan C. Cohen, Robert S. Kiss, et al. · Science · 1,109

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

2004 · Nan Wang, Debin Lan, et al. · Proceedings of the National Academy of Sciences · 1,061

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 · William R. Oliver, Jennifer L. Shenk, et al. · Proceedings of the National Academy of Sciences · 1,046

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

2000 · Asha Venkateswaran, Bryan A. Laffitte, et al. · Proceedings of the National Academy of Sciences · 1,004

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

2010 · S. Hani Najafi-Shoushtari, Fjoralba Kristo, et al. · Science · 957

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 · Sean B. Joseph, Elaine McKilligin, et al. · Proceedings of the National Academy of Sciences · 948

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

2005 · Matthew A. Kennedy, Gabriel C. Barrera, et al. · Cell Metabolism · 884

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Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

2002 · Joyce J. Repa, Knut E. Berge, et al. · Journal of Biological Chemistry · 852

Dysfunctional HDL and atherosclerotic cardiovascular disease

2015 · Robert S. Rosenson, H. Bryan Brewer, et al. · Nature Reviews Cardiology · 820

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

2011 · Mireille Ouimet, Vivian Franklin, et al. · Cell Metabolism · 774

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Foam cells in atherosclerosis

2013 · Xiao-Hua Yu, Yu-Chang Fu, et al. · Clinica Chimica Acta · 771

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Mechanisms of foam cell formation in atherosclerosis

2017 · Dimitry A. Chistiakov, Alexandra A. Melnichenko, et al. · Journal of Molecular Medicine · 745

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

2014 · Sima Allahverdian, Ali Cyrus Chehroudi, et al. · Circulation · 745

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

2014 · Siroon Bekkering, Jessica Quintin, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 731

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

2010 · Laurent Yvan-Charvet, Tamara Pagler, et al. · Science · 725

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

2011 · Katey J. Rayner, Christine C. Esau, et al. · Nature · 708

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

2020 · Lasse Folkersen, Stefan Gustafsson, et al. · Nature Metabolism · 702

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Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis

2004 · Harry R. Davis, Li-ji Zhu, et al. · Journal of Biological Chemistry · 699

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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

2011 · Katey J. Rayner, Frederick J. Sheedy, et al. · Journal of Clinical Investigation · 691

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 · Bryan A. Laffitte, Joyce J. Repa, et al. · Proceedings of the National Academy of Sciences · 683

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

2009 · Laurent Yvan-Charvet, Nan Wang, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 681

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Works count: 8,646

Citation count: 271,000