Keyword

abrin

Description: A highly toxic ribosome-inactivating protein found in rosary pea seeds that inhibits protein synthesis and is studied in toxicology and cell biology.

Primary topic: Toxin Mechanisms and Immunotoxins (61%)

Wikidata ID: wiki/Q331451

OpenAlex ID: keywords/abrin

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 · Y. Endo, K. Mitsui, et al. · Journal of Biological Chemistry · 1,151

Diphtheria toxin entry into cells is facilitated by low pH.

1980 · K Sandvig, S Olsnes · The Journal of Cell Biology · 461

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Mechanism of action of the toxic lectins abrin and ricin

1974 · Sjur Olsnes, Karin Refsnes, et al. · Nature · 440

The history of ricin, abrin and related toxins

2004 · Sjur Olsnes · Toxicon · 350

Isolation and Comparison of Galactose-binding Lectins from Abrus precatorius and Ricinus communis

1974 · Sjur Olsnes, Erling Saltvedt, et al. · Journal of Biological Chemistry · 342

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

1980 · Kristin Eiklid, Sjur Olsnes, et al. · Experimental Cell Research · 298

Mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes.

1986 · Y Endo, K Tsurugi · PubMed · 256

Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

1976 · K Sandvig, S Olsnes, et al. · Journal of Biological Chemistry · 238

Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles.

1982 · K Sandvig, S Olsnes · Journal of Biological Chemistry · 232

Isolation and Properties of Abrin: a Toxic Protein Inhibiting Protein Synthesis

1973 · Sjur Olsnes, Alexander Pihl · European Journal of Biochemistry · 186

Abrin and Ricin: New Anti-tumour Substances

1970 · JUNG-YAW LIN, KOU-YI TSERNG, et al. · Nature · 186

Suicide Transport: Destruction of Neurons by Retrograde Transport of Ricin, Abrin, and Modeccin

1982 · Ronald G. Wiley, W. W. Blessing, et al. · Science · 178

Isolation and properties of three lectins from mistletoe (Viscum album L.)

1981 · H Franz, P Ziska, et al. · Biochemical Journal · 166

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Biological Toxins as the Potential Tools for Bioterrorism

2019 · Edyta Janik, Michal Ceremuga, et al. · International Journal of Molecular Sciences · 160

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Abrin Poisoning

2003 · Kirsten J Dickers, Sally M Bradberry, et al. · Toxicological Reviews · 160

The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine

1987 · Gareth D. Griffiths, Michael D. Leek, et al. · The Journal of Pathology · 147

Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

2004 · Robert A. SPOONER, Peter D. WATSON, et al. · Biochemical Journal · 145

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Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium.

1982 · K Sandvig, S Olsnes · Journal of Biological Chemistry · 143

Immunotoxins for targeted cancer therapy

1998 · Robert J Kreitman, Ira Pastan · Advanced Drug Delivery Reviews · 135

The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods

2006 · Jijun Tang, Jianwei Xie, et al. · Electrophoresis · 132

Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review

2014 · Narendra Garaniya, Atul Bapodra · Asian Pacific Journal of Tropical Biomedicine · 128

Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice

1976 · Ø Fodstad, S Olsnes, et al. · British Journal of Cancer · 128

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Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin.

1976 · S Olsnes, K Sandvig, et al. · Journal of Biological Chemistry · 124

Experimentelle Untersuchungen über Immunität. II. Ueber Abrin

1891 · P. Ehrlich · DMW - Deutsche Medizinische Wochenschrift · 123

Cytotoxicity Acquired by Conjugation of an Anti‐Thy1.1 Monoclonal Antibody and the Ribosome‐Inactivating Protein, Gelonin

1981 · Philip E. THORPE, Alexander N. F. BROWN, et al. · European Journal of Biochemistry · 121

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Works count: 673

Citation count: 15,780