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Keyword

ACSL4

Description: A protein-coding gene encoding long-chain-fatty-acid-CoA ligase 4, an enzyme involved in lipid metabolism and studied in ferroptosis research.
Wikidata ID: wiki/Q17927175
OpenAlex ID: keywords/acsl4
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
2016 · Sebastian Doll, Bettina Proneth, et al. · Nature Chemical Biology · 4,217
Ferroptosis: machinery and regulation
2020 · Xin Chen, Jingbo Li, et al. · Autophagy · 2,083
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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
2020 · Guang Lei, Yilei Zhang, et al. · Cell Research · 1,308
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Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
2019 · Jiao Wu, Alexander M. Minikes, et al. · Nature · 1,104
Identification of ACSL4 as a biomarker and contributor of ferroptosis
2016 · Hua Yuan, Xuemei Li, et al. · Biochemical and Biophysical Research Communications · 1,063
Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
2015 · Scott J. Dixon, Georg E. Winter, et al. · ACS Chemical Biology · 1,034
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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
2022 · Peng Liao, Weimin Wang, et al. · Cancer Cell · 915
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
2019 · Bo Chu, Ning Kon, et al. · Nature Cell Biology · 882
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
2019 · Yang Li, Dongcheng Feng, et al. · Cell Death and Differentiation · 872
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Signaling pathways and defense mechanisms of ferroptosis
2021 · Jiao Liu, Rui Kang, et al. · FEBS Journal · 787
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ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation
2021 · Yu Cui, Yan Zhang, et al. · Brain Behavior and Immunity · 591
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
2022 · Hai-Liang Zhang, Bing-Xin Hu, et al. · Nature Cell Biology · 583
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
2022 · Yue Wang, Menghan Zhang, et al. · Redox Biology · 432
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications
2020 · Youbo Zhao, Menghuan Li, et al. · Cell Reports · 413
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Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress
2019 · Wenyuan Li, Wei Li, et al. · DNA and Cell Biology · 387
Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
2023 · Kaiyue Ding, Chongbin Liu, et al. · Chinese Medical Journal · 375
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway
2022 · Guang-Hui Chen, Chang-Chun Song, et al. · Free Radical Biology and Medicine · 372
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
2017 · Tammo Müller, Christin Dewitz, et al. · Cellular and Molecular Life Sciences · 357
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Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
2022 · Qing-zhang Tuo, Yu Liu, et al. · Signal Transduction and Targeted Therapy · 327
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Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury
2024 · Dan Wu, Charles B. Spencer, et al. · Redox Biology · 310
Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs
2023 · Ran Qi, Yixuan Bai, et al. · Drug Resistance Updates · 307
ACSL family: The regulatory mechanisms and therapeutic implications in cancer
2021 · Jing Quan, Ann M. Bode, et al. · European Journal of Pharmacology · 306
Ferroptosis involves in renal tubular cell death in diabetic nephropathy
2020 · Yue Wang, Ran Bi, et al. · European Journal of Pharmacology · 269
Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy
2021 · Xin Tang, Hui Ding, et al. · Thoracic Cancer · 257
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Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
2021 · Chong Li, Guangchi Sun, et al. · Pharmacological Research · 255
Works count: 2,907
Citation count: 61,110
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