Keyword

ACSS2

Description: ACSS2 is the gene encoding acyl-CoA synthetase short-chain family member 2, an enzyme involved in acetate metabolism and studied in molecular biology and medicine.

Primary topic: Cancer, Lipids, and Metabolism (33%)

Wikidata ID: wiki/Q18042148

OpenAlex ID: keywords/acss2

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

2015 · Zachary T. Schug, Barrie Peck, et al. · Cancer Cell · 818

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Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

2014 · Tomoyuki Mashimo, Kumar Pichumani, et al. · Cell · 759

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Acetate Dependence of Tumors

2014 · Sarah A. Comerford, Zhiguang Huang, et al. · Cell · 678

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Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

2020 · Steven Zhao, Cholsoon Jang, et al. · Nature · 547

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

2016 · Xue Gao, Shu-Hai Lin, et al. · Nature Communications · 482

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ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

2016 · Steven Zhao, AnnMarie Torres, et al. · Cell Reports · 393

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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

2017 · Xinjian Li, Willie Yu, et al. · Molecular Cell · 356

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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

2024 · Rongxuan Zhu, Xianglai Ye, et al. · Cell Metabolism · 312

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

2017 · Vinay Bulusu, Sergey Tumanov, et al. · Cell Reports · 266

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Alcohol metabolism contributes to brain histone acetylation

2019 · P. Mews, G. Egervari, et al. · Nature · 256

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

2017 · Ayano Kondo, Shogo Yamamoto, et al. · Cell Reports · 207

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Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation

2021 · Fengqi Hao, Miaomiao Tian, et al. · Proceedings of the National Academy of Sciences · 187

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

2021 · Patrick C. Bradshaw · Antioxidants · 180

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Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases

2020 · John R. Moffett, Narayanan Puthillathu, et al. · Frontiers in Physiology · 175

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HIV latency is reversed by ACSS2-driven histone crotonylation

2018 · Guochun Jiang, Don Nguyen, et al. · Journal of Clinical Investigation · 175

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Genome-wide association of milk fatty acids in Dutch dairy cattle

2011 · Aniek C Bouwman, Henk Bovenhuis, et al. · BMC Genetics · 168

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ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

2018 · Zhiguang Huang, Menglu Zhang, et al. · Proceedings of the National Academy of Sciences · 158

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

2015 · Elias Björnson, Bani Mukhopadhyay, et al. · Cell Reports · 143

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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer

2023 · Katelyn D. Miller, Seamus O’Connor, et al. · Nature Cancer · 126

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Acetate controls endothelial-to-mesenchymal transition

2023 · Xiaolong Zhu, Yunyun Wang, et al. · Cell Metabolism · 123

ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms

2012 · Nousheen Zaidi, Ines Royaux, et al. · Molecular Cancer Therapeutics · 116

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease

2020 · John R. Moffett, Narayanan Puthillathu, et al. · Frontiers in Physiology · 115

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Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence

2024 · Lingzhi Li, Ting Xiang, et al. · Nature Communications · 112

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The Importance of Acetyl Coenzyme A Synthetase for 11C-Acetate Uptake and Cell Survival in Hepatocellular Carcinoma

2009 · Mijin Yun, Seong-Hye Bang, et al. · Journal of Nuclear Medicine · 109

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Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

2009 · Yukie Yoshii, Takako Furukawa, et al. · Cancer Science · 108

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Works count: 500

Citation count: 11,600