Keyword

actionable mutations

Description: Genetic alterations with potential clinical utility because they can inform diagnosis, prognosis, or selection of targeted treatment, especially in cancer.

Primary topic: Cancer Genomics and Diagnostics (37%)

OpenAlex ID: keywords/actionable-mutations

Hepatocellular carcinoma

2021 · Josep M. Llovet, Robin Kate Kelley, et al. · Nature Reviews Disease Primers · 6,990

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The Molecular Taxonomy of Primary Prostate Cancer

2015 · Adam Abeshouse, Jaeil Ahn, et al. · Cell · 3,114

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OncoKB: A Precision Oncology Knowledge Base

2017 · Debyani Chakravarty, Jianjiong Gao, et al. · JCO Precision Oncology · 2,696

Comprehensive Characterization of Cancer Driver Genes and Mutations

2018 · Matthew H. Bailey, Collin Tokheim, et al. · Cell · 2,299

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Liquid Biopsies: Genotyping Circulating Tumor DNA

2014 · Luis A. Diaz, Alberto Bardelli · Journal of Clinical Oncology · 2,207

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

2013 · Garrett M Frampton, Alex Fichtenholtz, et al. · Nature Biotechnology · 2,156

Hepatocellular Carcinoma.

1977 · Annals of Internal Medicine · 2,081

Molecular therapies and precision medicine for hepatocellular carcinoma

2018 · Josep M. Llovet, Robert Montal, et al. · Nature Reviews Clinical Oncology · 1,940

Whole-genome landscapes of major melanoma subtypes

2017 · Nicholas K. Hayward, James S. Wilmott, et al. · Nature · 1,463

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Non–Small Cell Lung Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology

2022 · David S. Ettinger, Douglas E. Wood, et al. · Journal of the National Comprehensive Cancer Network · 1,393

Enhanced detection of circulating tumor DNA by fragment size analysis

2018 · Florent Mouliere, Dineika Chandrananda, et al. · Science Translational Medicine · 1,071

Intratumor Heterogeneity: Evolution through Space and Time

2012 · Charles Swanton · Cancer Research · 929

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The Dualistic Model of Ovarian Carcinogenesis

2016 · Robert J. Kurman, Ie-Ming Shih · American Journal Of Pathology · 924

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Advances in Risk Classification and Treatment Strategies for Neuroblastoma

2015 · Navin R. Pinto, Mark A. Applebaum, et al. · Journal of Clinical Oncology · 913

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

2015 · Leticia De Mattos-Arruda, Regina Mayor, et al. · Nature Communications · 867

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ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

2022 · J. Pascual, G. Attard, et al. · Annals of Oncology · 758

Genomic Evolution of Breast Cancer Metastasis and Relapse

2017 · Lucy R. Yates, Stian Knappskog, et al. · Cancer Cell · 665

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Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies

2017 · Emmet J. Jordan, Hyunjae R. Kim, et al. · Cancer Discovery · 640

Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

2014 · Hongdo Do, Alexander Dobrovic · Clinical Chemistry · 572

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

2023 · Jesse J Swen, Cathelijne H van der Wouden, et al. · The Lancet · 557

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COSMIC: a curated database of somatic variants and clinical data for cancer

2023 · Zbyslaw Sondka, Nidhi Bindal Dhir, et al. · Nucleic Acids Research · 534

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Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

2013 · Zhengyan Kan, Hancheng Zheng, et al. · Genome Research · 523

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High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden

2019 · Ryma Benayed, Michael Offin, et al. · Clinical Cancer Research · 484

Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

2009 · Laura E. MacConaill, Catarina D. Campbell, et al. · PLoS ONE · 438

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Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies

2018 · Justin I. Odegaard, John J. Vincent, et al. · Clinical Cancer Research · 436

Works count: 3,260

Citation count: 73,100