Keyword

ACVR1

Description: ACVR1 is a human gene encoding a receptor in the bone morphogenetic protein signaling pathway, studied in development and disease.

Primary topic: Heterotopic Ossification and Related Conditions (34%)

Wikidata ID: wiki/Q14905142

OpenAlex ID: keywords/acvr1

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

2006 · Eileen M Shore, Meiqi Xu, et al. · Nature Genetics · 1,216

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

2014 · Gang Wu, Yongjin Li, et al. · Nature Genetics · 1,104

BMP type I receptor inhibition reduces heterotopic ossification

2008 · Paul B Yu, Donna Y Deng, et al. · Nature Medicine · 635

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

2008 · Frederick S. Kaplan, Meiqi Xu, et al. · Human Mutation · 437

The new bone biology: Pathologic, molecular, and clinical correlates

2006 · M. Michael Cohen Jr. · American Journal of Medical Genetics Part A · 335

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

2015 · Kyosuke Hino, Makoto Ikeya, et al. · Proceedings of the National Academy of Sciences · 315

The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations

2004 · J R Howe, M G Sayed, et al. · Journal of Medical Genetics · 269

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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

2016 · Hamid Nikbakht, Eshini Panditharatna, et al. · Nature Communications · 254

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A New Class of Small Molecule Inhibitor of BMP Signaling

2013 · Caroline E. Sanvitale, Georgina Kerr, et al. · PLoS ONE · 241

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The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization

2009 · Qi Shen, Shawn C. Little, et al. · Journal of Clinical Investigation · 216

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TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

2018 · Anassuya Ramachandran, Pedro Vizán, et al. · eLife · 203

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

2017 · Mark A. Petersen, Jae Kyu Ryu, et al. · Neuron · 201

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Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway

2021 · Anqi Liu, Dan Lin, et al. · Biomaterials · 200

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

2016 · Lindsey M. Hoffman, Mariko DeWire, et al. · Acta Neuropathologica Communications · 199

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An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva

2012 · Salin A Chakkalakal, Deyu Zhang, et al. · Journal of Bone and Mineral Research · 191

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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

2011 · Andrea U. Steinbicker, Thomas B. Bartnikas, et al. · Blood · 181

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MicroRNA-30c promotes human adipocyte differentiation and co-repressesPAI-1andALK2

2011 · Michael Karbiener, Claudia Neuhold, et al. · RNA Biology · 131

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Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis

2012 · Frederick S. Kaplan, Salin A. Chakkalakal, et al. · Disease Models & Mechanisms · 129

Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

2016 · Haitao Wang, Carter Lindborg, et al. · Journal of Bone and Mineral Research · 124

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Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

2020 · Gonzalo Sanchez-Duffhues, Eleanor Williams, et al. · Bone · 118

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ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

2019 · Diana Carvalho, Kathryn R. Taylor, et al. · Communications Biology · 118

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A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7

2006 · Emma-Leena Alarmo, Tuula Kuukasjärvi, et al. · Breast Cancer Research and Treatment · 117

Functional Redundancy of TGF-beta Family Type I Receptors and Receptor-Smads in Mediating Anti-Müllerian Hormone-Induced Müllerian Duct Regression in the Mouse1

2008 · G.D. Orvis, S.P. Jamin, et al. · Biology of Reproduction · 112

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Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon

2016 · Shailesh Agarwal, Shawn J. Loder, et al. · Stem Cells · 111

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Mutational analysis of the ACVR1 gene in Italian patients affected with fibrodysplasia ossificans progressiva: confirmations and advancements

2008 · Renata Bocciardi, Domenico Bordo, et al. · European Journal of Human Genetics · 102

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Works count: 678

Citation count: 13,430