Keyword

ADAM17

Description: A cell-surface metalloprotease enzyme involved in shedding proteins from cell membranes and regulating signaling in biological processes and disease.

Primary topic: Protease and Inhibitor Mechanisms (22%)

OpenAlex ID: keywords/adam17

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 · Jacques J. Peschon, Jennifer L. Slack, et al. · Science · 1,607

The ADAM metalloproteinases

2008 · D EDWARDS, M HANDSLEY, et al. · Molecular Aspects of Medicine · 1,164

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

2003 · Darren F. Seals, Sara A. Courtneidge · Genes & Development · 1,062

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 · Umut Sahin, Gisela Weskamp, et al. · The Journal of Cell Biology · 979

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 · Joseph D. Buxbaum, Kang-Nian Liu, et al. · Journal of Biological Chemistry · 934

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TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

2013 · Adeline Heurich, Heike Hofmann-Winkler, et al. · Journal of Virology · 882

Matrix metalloproteinases (MMPs) in health and disease: an overview

2006 · Charles, J. Malemud · Frontiers in bioscience · 704

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Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)

2005 · Daniel W. Lambert, Mike Yarski, et al. · Journal of Biological Chemistry · 695

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

2001 · Kyle J. Garton, Peter J. Gough, et al. · Journal of Biological Chemistry · 639

ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

2010 · Peer‐Hendrik Kuhn, Huanhuan Wang, et al. · The EMBO Journal · 621

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TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 · Augustin Amour, Patrick M Slocombe, et al. · FEBS Letters · 609

MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma #

2008 · Wei-Chih Tsai, Paul Wei-Che Hsu, et al. · Hepatology · 583

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

2013 · Rizwan Romee, Bree Foley, et al. · Blood · 552

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

2007 · Ci-Di Chen, Sonia Podvin, et al. · Proceedings of the National Academy of Sciences · 548

ADAMs in cancer cell proliferation and progression

2007 · Satsuki Mochizuki, Yasunori Okada · Cancer Science · 546

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ADAM17: a molecular switch to control inflammation and tissue regeneration

2011 · Jürgen Scheller, Athena Chalaris, et al. · Trends in Immunology · 526

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

2012 · Christine M. Ardito, Barbara M. Grüner, et al. · Cancer Cell · 518

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 · T G Wolfsberg, P Primakoff, et al. · The Journal of Cell Biology · 502

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 · Pranhitha Reddy, Jennifer L. Slack, et al. · Journal of Biological Chemistry · 501

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ADAMs: focus on the protease domain

1998 · Roy A Black, Judith M White · Current Opinion in Cell Biology · 467

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

2013 · Jia Lu, Xiangcang Ye, et al. · Cancer Cell · 447

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The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

2001 · W. Taylor Kimberly, Jessica B. Zheng, et al. · Journal of Biological Chemistry · 444

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ADAMs family members as amyloid precursor protein α‐secretases

2003 · Tobias M.J. Allinson, Edward T. Parkin, et al. · Journal of Neuroscience Research · 440

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-γ and TNF-α and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10

2004 · Soeren Abel, Christian Hundhausen, et al. · The Journal of Immunology · 437

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

2009 · Erica M Hanson, Virginia K Clements, et al. · The Journal of Immunology · 427

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Works count: 4,713

Citation count: 128,100