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Keyword

AG490

Description: A small-molecule tyrosine kinase inhibitor used in experimental studies of cell signaling, inflammation, and cancer biology.
Wikidata ID: wiki/Q27074341
OpenAlex ID: keywords/ag490
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
1996 · Naftaly Meydan, Tom Grunberger, et al. · Nature · 897
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
2001 · Hirohide Yoshikawa, Kenichi Matsubara, et al. · Nature Genetics · 722
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
2001 · P.K. Epling-Burnette, Jin Hong Liu, et al. · Journal of Clinical Investigation · 634
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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells
2003 · Alok C Bharti, Nicholas Donato, et al. · The Journal of Immunology · 508
Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)
2006 · Seung-Jin Lee, Byeong-Churl Jang, et al. · FEBS Letters · 446
Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer
2006 · BHARAT B. AGGARWAL, GAUTAM SETHI, et al. · Annals of the New York Academy of Sciences · 398
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
2006 · A Iwamaru, S Szymanski, et al. · Oncogene · 370
IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway
2017 · Xiongyan Wu, Pan Tao, et al. · Oncotarget · 367
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MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2
2010 · Ling Ding, Yanjun Xu, et al. · Cell Research · 341
Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
2008 · M Colomiere, A C Ward, et al. · British Journal of Cancer · 320
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JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
2014 · RENG-YUN LIU, YUANYUAN ZENG, et al. · International Journal of Oncology · 309
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SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
2003 · Oliver Galm, Hirohide Yoshikawa, et al. · Blood · 308
Mitochondrial STAT3 Activation and Cardioprotection by Ischemic Postconditioning in Pigs With Regional Myocardial Ischemia/Reperfusion
2011 · Gerd Heusch, Judith Musiolik, et al. · Circulation Research · 303
STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells
2004 · Naoki Kanda, Hiroshi Seno, et al. · Oncogene · 302
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STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells
2005 · Sujoy Bhattacharya, Ramesh M. Ray, et al. · Biochemical Journal · 291
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The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
2006 · Catriona H. M. Jamieson, Jason Gotlib, et al. · Proceedings of the National Academy of Sciences · 286
An essential role of the JAK-STAT pathway in ischemic preconditioning
2001 · Yu-Ting Xuan, Yiru Guo, et al. · Proceedings of the National Academy of Sciences · 285
Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation
2005 · Jin Qiu, William B. J. Cafferty, et al. · Journal of Neuroscience · 279
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Role of NAD(P)H Oxidase in Angiotensin II–Induced JAK/STAT Signaling and Cytokine Induction
2000 · Bernhard Schieffer, Maren Luchtefeld, et al. · Circulation Research · 273
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Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
2003 · Virote Sriuranpong, Jong In Park, et al. · PubMed · 272
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
2001 · William M Burke, Xiaohong Jin, et al. · Oncogene · 269
JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
2008 · Elisa Dominguez, Cyril Rivat, et al. · Journal of Neurochemistry · 256
IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro
2017 · Qing Wu, Xiaokang Zhou, et al. · Cellular Physiology and Biochemistry · 245
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.
2003 · Steve Alas, Benjamin Bonavida · PubMed · 240
JAK 2/ STAT 3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury
2013 · Yang Yang, Weixun Duan, et al. · Journal of Pineal Research · 232
Works count: 1,723
Citation count: 46,480
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