Keyword

AICAR

Description: A chemical compound used in biomedical research as an activator of AMP-activated protein kinase and as a pharmacological agent.

Primary topic: Metabolism, Diabetes, and Cancer (25%)

Wikidata ID: wiki/Q2817102

OpenAlex ID: keywords/aicar

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

1995 · Julia M. Corton, John G. Gillespie, et al. · European Journal of Biochemistry · 1,230

AMPK and PPARδ Agonists Are Exercise Mimetics

2008 · Vihang A. Narkar, Michael Downes, et al. · Cell · 1,219

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AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

1997 · G. F. Merrill, E. J. Kurth, et al. · American Journal of Physiology-Endocrinology and Metabolism · 1,027

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

2005 · Rebecca L. Hurley, Kristin A. Anderson, et al. · Journal of Biological Chemistry · 1,018

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Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

2007 · Monica Buzzai, Russell G. Jones, et al. · Cancer Research · 923

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A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 · James Mu, Joseph T Brozinick, et al. · Molecular Cell · 921

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AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 · Douglas R. Bolster, Stephen J. Crozier, et al. · Journal of Biological Chemistry · 851

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Regulation of nitric oxide (NO) production by plant nitrate reductase in vivo and in vitro

2002 · Peter Rockel, Frank Strube, et al. · Journal of Experimental Botany · 799

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Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

1998 · Tatsuya Hayashi, Michael F Hirshman, et al. · Diabetes · 775

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

2010 · Simon A. Hawley, Fiona A. Ross, et al. · Cell Metabolism · 774

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Resveratrol stimulates AMP kinase activity in neurons

2007 · Biplab Dasgupta, Jeffrey Milbrandt · Proceedings of the National Academy of Sciences · 723

Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle

2000 · W. W. Winder, B. F. Holmes, et al. · Journal of Applied Physiology · 710

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 · B N Cronstein, D Naime, et al. · Journal of Clinical Investigation · 681

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Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

2016 · Hyo Youl Moon, Andreas Becke, et al. · Cell Metabolism · 625

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Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis

2007 · Richard M. Reznick, Haihong Zong, et al. · Cell Metabolism · 552

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Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

2004 · Sebastian B. Jørgensen, Benoit Viollet, et al. · Journal of Biological Chemistry · 552

Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR

1999 · Raymond R. Russell, Raynald Bergeron, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 552

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

2005 · Kei Sakamoto, Afshan McCarthy, et al. · The EMBO Journal · 544

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Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

2006 · Daisuke Kukidome, Takeshi Nishikawa, et al. · Diabetes · 504

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Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

1999 · B. F. Holmes, E. J. Kurth-Kraczek, et al. · Journal of Applied Physiology · 489

Metformin Inhibits Cytokine-Induced Nuclear Factor κB Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells

2006 · Yoshiyuki Hattori, Kunihiro Suzuki, et al. · Hypertension · 486

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase

1994 · Jane E. Sullivan, Katy J. Brocklehurst, et al. · FEBS Letters · 485

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The Association of AMPK with ULK1 Regulates Autophagy

2010 · Jong Woo Lee, Sungman Park, et al. · PLoS ONE · 481

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The role of AMP-activated protein kinase in the action of ethanol in the liver

2004 · Min You, Michinaga Matsumoto, et al. · Gastroenterology · 470

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AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

2006 · Daniel Meley, Chantal Bauvy, et al. · Journal of Biological Chemistry · 463

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Works count: 3,358

Citation count: 121,000