Keyword

ALK1

Description: ALK1 is a cell-surface receptor protein encoded by ACVRL1 that participates in transforming growth factor beta signaling, particularly in vascular biology.

Primary topic: Vascular Anomalies and Treatments (25%)

Wikidata ID: wiki/Q14914463

OpenAlex ID: keywords/alk1

Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)

2000 · Claire L. Shovlin, Alan E. Guttmacher, et al. · American Journal of Medical Genetics · 1,746

Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

2002 · Marie‐José Goumans, Gudrun Valdimarsdottir, et al. · The EMBO Journal · 1,125

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Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 · D.W. Johnson, J.N. Berg, et al. · Nature Genetics · 1,116

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 · S. Paul Oh, Tsugio Seki, et al. · Proceedings of the National Academy of Sciences · 852

A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)

2004 · Carol J Gallione, Gabriela M Repetto, et al. · The Lancet · 756

Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era

2015 · Jamie McDonald, Whitney Wooderchak-Donahue, et al. · Frontiers in Genetics · 727

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Clinical and Molecular Genetic Features of Pulmonary Hypertension in Patients with Hereditary Hemorrhagic Telangiectasia

2001 · Richard C. Trembath, Jennifer R. Thomson, et al. · New England Journal of Medicine · 725

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Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

2006 · Laurent David, Christine Mallet, et al. · Blood · 708

Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

2003 · Marie-José Goumans, Gudrun Valdimarsdottir, et al. · Molecular Cell · 688

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Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

2004 · Franck Lebrin, Marie‐José Goumans, et al. · The EMBO Journal · 652

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ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor

2001 · Cheryl M Coffin, Ankita Patel, et al. · Modern Pathology · 627

Genetics and Genomics of Pulmonary Arterial Hypertension

2013 · Florent Soubrier, Wendy K. Chung, et al. · Journal of the American College of Cardiology · 617

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Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice

2001 · Jonas Larsson, Marie‐José Goumans, et al. · The EMBO Journal · 562

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LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

2013 · Xiaomeng Wang, Sabu Abraham, et al. · Nature · 540

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

2007 · Marion Scharpfenecker, M. van Dinther, et al. · Journal of Cell Science · 531

TGF-? receptor function in the endothelium

2004 · F LEBRIN, M DECKERS, et al. · Cardiovascular Research · 514

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

2010 · Claire L. Shovlin · Blood Reviews · 503

Hereditary haemorrhagic telangiectasia: a clinical and scientific review

2009 · Fatima S Govani, Claire L Shovlin · European Journal of Human Genetics · 491

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Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 · Marina Macı́as-Silva, Pamela A. Hoodless, et al. · Journal of Biological Chemistry · 476

Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-β 1 and Bone Morphogenetic Proteins

2001 · Nicholas W. Morrell, Xudong Yang, et al. · Circulation · 453

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

2000 · Lisa D. Urness, Lise K. Sorensen, et al. · Nature Genetics · 440

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

2008 · Laurent David, Christine Mallet, et al. · Circulation Research · 417

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Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 · Makiko Fujii, Kohsuke Takeda, et al. · Molecular Biology of the Cell · 415

Signaling by members of the TGF-β family in vascular morphogenesis and disease

2010 · Evangelia Pardali, Marie-José Goumans, et al. · Trends in Cell Biology · 401

Expression of ALK1 and p80 in Inflammatory Myofibroblastic Tumor and Its Mesenchymal Mimics: A Study of 135 Cases

2002 · Melissa H. Cessna, Holly Zhou, et al. · Modern Pathology · 393

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Works count: 2,067

Citation count: 64,220