Keyword

ALK5

Description: ALK5 is a type I transforming growth factor beta receptor, a cell-surface kinase involved in TGF-β signaling.

Primary topic: TGF-β signaling in diseases (38%)

Related topic: TGF-β signaling in diseases (38%)

OpenAlex ID: keywords/alk5

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 · Gareth J. Inman, Francisco J. Nicolás, et al. · Molecular Pharmacology · 1,634

TGF-β signaling in fibrosis

2011 · Anna Biernacka, Marcin Dobaczewski, et al. · Growth Factors · 1,164

Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

2002 · Marie‐José Goumans, Gudrun Valdimarsdottir, et al. · The EMBO Journal · 1,125

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Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 · S. Paul Oh, Tsugio Seki, et al. · Proceedings of the National Academy of Sciences · 852

Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling

2003 · Marie-José Goumans, Gudrun Valdimarsdottir, et al. · Molecular Cell · 688

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Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction

2004 · Franck Lebrin, Marie‐José Goumans, et al. · The EMBO Journal · 652

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Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 · N.J. Laping, E. Grygielko, et al. · Molecular Pharmacology · 635

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

2003 · A. Rebbapragada, H. Benchabane, et al. · Molecular and Cellular Biology · 566

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 · Peter ten Dijke, Hidetoshi Yamashita, et al. · Science · 551

TGF-? receptor function in the endothelium

2004 · F LEBRIN, M DECKERS, et al. · Cardiovascular Research · 514

Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-β1-Induced Extracellular Matrix Expression

2005 · Masatoshi Jinnin, Hironobu Ihn, et al. · Molecular Pharmacology · 445

p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration

2002 · Andrei V. Bakin, Cammie Rinehart, et al. · Journal of Cell Science · 431

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 · Ester Piek, Aristidis Moustakas, et al. · Journal of Cell Science · 426

SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7

2004 · Stacey DaCosta Byfield, Christopher Major, et al. · Molecular Pharmacology · 414

Controlling the Angiogenic Switch

2003 · Marie-Jose Goumans, Franck Lebrin, et al. · Trends in Cardiovascular Medicine · 339

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

2002 · James F. Callahan, Joelle L. Burgess, et al. · Journal of Medicinal Chemistry · 308

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

2009 · Esmeralda N Blaney Davidson, Dennis F G Remst, et al. · The Journal of Immunology · 302

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Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1998 · M Goggins, M Shekher, et al. · PubMed · 288

Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

2008 · Amanda C. Daly, Rebecca A. Randall, et al. · Molecular and Cellular Biology · 278

Losartan prevents acquired epilepsy via TGF‐β signaling suppression

2014 · Guy Bar‐Klein, Luisa P. Cacheaux, et al. · Annals of Neurology · 269

Transforming Growth Factor-β Signal Transduction in Angiogenesis and Vascular Disorders

2005 · Philippe Bertolino, Martine Deckers, et al. · CHEST Journal · 264

Growth Differentiation Factor-9 Signaling Is Mediated by the Type I Receptor, Activin Receptor-Like Kinase 5

2003 · Sabine Mazerbourg, Cynthia Klein, et al. · Molecular Endocrinology · 256

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

2007 · Sung O. Park, Young Jae Lee, et al. · Blood · 227

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Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors

2004 · Françoise Gellibert, James Woolven, et al. · Journal of Medicinal Chemistry · 224

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

2020 · Andrew J. Gunderson, Tomoko Yamazaki, et al. · Nature Communications · 221

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Works count: 1,170

Citation count: 42,340