Get started
Keyword

APC mutation

Description: A genetic alteration in the APC tumor-suppressor gene, studied in cancer genetics and disorders such as familial adenomatous polyposis.
OpenAlex ID: keywords/apc-mutation
Clues to the Pathogenesis of Familial Colorectal Cancer
1993 · Lauri A. Aaltonen, Päivi Peltomäki, et al. · Science · 2,710
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
2015 · Marc van de Wetering, Hayley E. Francies, et al. · Cell · 2,404
PDF
APC mutations occur early during colorectal tumorigenesis
1992 · Steven M. Powell, Nathan Zilz, et al. · Nature · 1,926
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
2005 · Johan H. van Es, Marielle E. van Gijn, et al. · Nature · 1,543
Caught up in a Wnt storm: Wnt signaling in cancer
2003 · Rachel H. Giles, Johan H. van Es, et al. · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 1,482
Detection and quantification of mutations in the plasma of patients with colorectal tumors
2005 · Frank Diehl, Meng Li, et al. · Proceedings of the National Academy of Sciences · 1,188
Sequential cancer mutations in cultured human intestinal stem cells
2015 · Jarno Drost, Richard H. van Jaarsveld, et al. · Nature · 1,089
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
2004 · Hiromu Suzuki, D Neil Watkins, et al. · Nature Genetics · 1,069
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
2000 · Seiji Satoh, Yataro Daigo, et al. · Nature Genetics · 961
Recurrent R-spondin fusions in colon cancer
2012 · Somasekar Seshagiri, Eric W. Stawiski, et al. · Nature · 960
PDF
Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH
2003 · Oliver M. Sieber, Lara Lipton, et al. · New England Journal of Medicine · 862
Wnt/β-catenin signaling in cancer stemness and malignant behavior
2007 · Riccardo Fodde, Thomas Brabletz · Current Opinion in Cell Biology · 785
Guidelines for the clinical management of familial adenomatous polyposis (FAP)
2008 · H F A Vasen, G Möslein, et al. · Gut · 704
PDF
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
1997 · Steven J. Laken, Gloria M. Petersen, et al. · Nature Genetics · 683
Alleles of the APC gene: An attenuated form of familial polyposis
1993 · Lisa Spirio, Sylviane Olschwang, et al. · Cell · 622
PDF
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
2008 · Kevin M Haigis, Krystle R Kendall, et al. · Nature Genetics · 610
Familial adenomatous polyposis
2009 · Elizabeth Half, Dani Bercovich, et al. · Orphanet Journal of Rare Diseases · 602
PDF
Colorectal cancer and genetic alterations in the Wnt pathway
2006 · S Segditsas, I Tomlinson · Oncogene · 591
Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature
2018 · Burcin Baran, Nazli Mert Ozupek, et al. · Gastroenterology Research · 552
PDF
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.
1996 · S K Boolbol, A J Dannenberg, et al. · PubMed · 546
Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin
2005 · Thomas Brabletz, Falk Hlubek, et al. · Cells Tissues Organs · 528
Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
1999 · Vera J.M. Wielenga, Ron Smits, et al. · American Journal Of Pathology · 512
PDF
Role of matrix metalloproteinases (MMPs) in colorectal cancer
2003 · Stanley Zucker, Jeffrey Vacirca · Cancer and Metastasis Reviews · 506
Molecular determinants of dysplasia in colorectal lesions.
1994 · J Jen, S M Powell, et al. · PubMed · 505
Emerging concepts in colorectal neoplasia
2002 · Jeremy R. Jass, Vicki L.J. Whitehall, et al. · Gastroenterology · 497
Works count: 4,486
Citation count: 120,100
Year
Topic
Type