Keyword

APP processing

Description: The enzymatic cleavage and intracellular handling of amyloid precursor protein, studied in Alzheimer’s disease and related biological research.

Primary topic: Alzheimer's disease research and treatments (89%)

OpenAlex ID: keywords/app-processing

Amyloid Precursor Protein Processing and Alzheimer's Disease

2011 · Richard J. O'Brien, Philip C. Wong · Annual Review of Neuroscience · 2,053

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 · Bart De Strooper, Paul Saftig, et al. · Nature · 1,817

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 · Karen Duff, Chris Eckman, et al. · Nature · 1,465

Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

2011 · Joseph M. Castellano, Jungsu Kim, et al. · Science Translational Medicine · 1,192

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 · Sven Lammich, Elzbieta Kojro, et al. · Proceedings of the National Academy of Sciences · 1,145

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 · Robert Ehehalt, Patrick Keller, et al. · The Journal of Cell Biology · 1,107

Trafficking and Proteolytic Processing of APP

2012 · C. Haass, C. Kaether, et al. · Cold Spring Harbor Perspectives in Medicine · 1,074

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Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 · Lorenzo M. Refolo, Miguel A. Pappolla, et al. · Neurobiology of Disease · 1,002

APP processing in Alzheimer's disease

2011 · Yun-wu Zhang, Robert Thompson, et al. · Molecular Brain · 981

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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

2005 · W. Haung Yu, Ana Maria Cuervo, et al. · The Journal of Cell Biology · 966

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 · Roger M. Nitsch, Barbara E. Slack, et al. · Science · 898

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 · S. S. Sisodia, E. H. Koo, et al. · Science · 893

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 · Yue-Ming Li, Min Xu, et al. · Nature · 867

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 · Christian Haass, Dennis J. Selkoe · Cell · 833

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 · D J Selkoe · Annual Review of Neuroscience · 818

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

2005 · Paul A. Adlard, Victoria M. Perreau, et al. · Journal of Neuroscience · 805

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 · Mark P. Mattson, Bin Cheng, et al. · Neuron · 805

Inflammatory processes in Alzheimer's disease

2007 · Michael T. Heneka, M. Kerry O'Banion · Journal of Neuroimmunology · 783

The Pathogenesis of Senile Plaques

1997 · DENNIS W. DICKSON · Journal of Neuropathology & Experimental Neurology · 753

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

1998 · W.S.T. Griffin, J.G. Sheng, et al. · Brain Pathology · 708

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 · Hui Zheng, Minghao Jiang, et al. · Cell · 704

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β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

2002 · Hiroaki Fukumoto · Archives of Neurology · 701

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

2005 · Masashi Kitazawa, Salvatore Oddo, et al. · Journal of Neuroscience · 696

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A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

2005 · Giselle P. Lim, Frédéric Calon, et al. · Journal of Neuroscience · 686

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An Overview of APP Processing Enzymes and Products

2009 · Vivian W. Chow, Mark P. Mattson, et al. · NeuroMolecular Medicine · 682

Works count: 4,923

Citation count: 204,400