Keyword

ASC

Description: ASC is an adaptor protein that assembles inflammasome complexes and helps activate innate immune responses to cellular danger signals.

Primary topic: Inflammasome and immune disorders (55%)

OpenAlex ID: keywords/asc

The Inflammasome

2002 · Fabio Martinon, Kimberly Burns, et al. · Molecular Cell · 6,049

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

2010 · Peter Duewell, Hajime Kono, et al. · Nature · 4,006

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

2009 · Veit Hornung, Andrea Ablasser, et al. · Nature · 2,617

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

2015 · Wan-ting He, Haoqiang Wan, et al. · Cell Research · 2,498

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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

2011 · Eran Elinav, Till Strowig, et al. · Cell · 2,018

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 · Sanjeev Mariathasan, Kim Newton, et al. · Nature · 1,839

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

2009 · Teresa Fernandes-Alnemri, Je-Wook Yu, et al. · Nature · 1,824

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 · Laetitia Agostini, Fabio Martinon, et al. · Immunity · 1,766

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

2008 · Stephanie C. Eisenbarth, Oscar R. Colegio, et al. · Nature · 1,534

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

2014 · Alvin Lu, Venkat Giri Magupalli, et al. · Cell · 1,344

Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation

2023 · Jianing Fu, Hao Wu · Annual Review of Immunology · 1,187

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Caspase‐1‐induced pyroptotic cell death

2011 · Edward A. Miao, Jayant V. Rajan, et al. · Immunological Reviews · 1,139

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

2009 · Tilmann Bürckstümmer, Christoph Baumann, et al. · Nature Immunology · 1,090

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

2007 · T Fernandes-Alnemri, J Wu, et al. · Cell Death and Differentiation · 1,023

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The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

2010 · Md. Hasan Zaki, Kelli L. Boyd, et al. · Immunity · 987

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Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 · Fayyaz S. Sutterwala, Yasunori Ogura, et al. · Immunity · 976

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

2008 · Daniel A. Muruve, Virginie Pétrilli, et al. · Nature · 936

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

2010 · Christian Bauer, Peter Duewell, et al. · Gut · 907

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Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

2018 · Richard Gordon, Eduardo A. Albornoz, et al. · Science Translational Medicine · 889

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

2008 · Mihai G. Netea, Claudia A. Nold-Petry, et al. · Blood · 793

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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

2021 · SangJoon Lee, Rajendra Karki, et al. · Nature · 786

Human Monocytes Engage an Alternative Inflammasome Pathway

2016 · Moritz M. Gaidt, Thomas S. Ebert, et al. · Immunity · 786

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

2014 · Bernardo S Franklin, Lukas Bossaller, et al. · Nature Immunology · 774

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

2012 · Hye-Mi Lee, Jwa-Jin Kim, et al. · Diabetes · 734

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Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 · Thirumala-Devi Kanneganti, Mathilde Body-Malapel, et al. · Journal of Biological Chemistry · 711

Works count: 3,411

Citation count: 160,700