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Keyword

ASCT2

Description: ASCT2 is a sodium-dependent transporter encoded by SLC1A5 that carries neutral amino acids across cell membranes, including in cancer cells.
Wikidata ID: wiki/Q18031524
OpenAlex ID: keywords/asct2
Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
2014 · Mako Nakaya, Yichuan Xiao, et al. · Immunity · 868
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Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
2008 · Vadivel Ganapathy, Muthusamy Thangaraju, et al. · Pharmacology & Therapeutics · 711
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
2005 · Bryan C. Fuchs, Barrie P. Bode · Seminars in Cancer Biology · 680
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
2015 · M van Geldermalsen, Q Wang, et al. · Oncogene · 580
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Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter
1996 · Naoko Utsunomiya-Tate, Hitoshi Endou, et al. · Journal of Biological Chemistry · 530
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
2018 · Michael L Schulte, Allie Fu, et al. · Nature Medicine · 492
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
2004 · Yoshikatsu Kanai, Matthias A. Hediger · Pflügers Archiv - European Journal of Physiology · 450
Targeting ASCT2 ‐mediated glutamine uptake blocks prostate cancer growth and tumour development
2015 · Qian Wang, Rae‐Anne Hardie, et al. · The Journal of Pathology · 339
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The SLC1 high-affinity glutamate and neutral amino acid transporter family
2013 · Yoshikatsu Kanai, Benjamin Clémençon, et al. · Molecular Aspects of Medicine · 328
Transfer of glutamine between astrocytes and neurons
2001 · Stefan Bröer, Neville Brookes · Journal of Neurochemistry · 325
Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification
2014 · Leal Oburoglu, Saverio Tardito, et al. · Cell stem cell · 291
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The Human SLC1A5 (ASCT2) Amino Acid Transporter: From Function to Structure and Role in Cell Biology
2018 · Mariafrancesca Scalise, Lorena Pochini, et al. · Frontiers in Cell and Developmental Biology · 265
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Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
2016 · Angelika Bröer, Farid Rahimi, et al. · Journal of Biological Chemistry · 253
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Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
2014 · Lorena Pochini, Mariafrancesca Scalise, et al. · Frontiers in Chemistry · 250
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The Astroglial ASCT2 Amino Acid Transporter as a Mediator of Glutamine Efflux
1999 · A Bröer, N Brookes, et al. · Journal of Neurochemistry · 239
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Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
2015 · Jhudit Pérez-Escuredo, Rajesh K Dadhich, et al. · Cell Cycle · 230
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Targeting glutamine transport to suppress melanoma cell growth
2014 · Qian Wang, Kimberley A. Beaumont, et al. · International Journal of Cancer · 224
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Control of glutamine metabolism by the tumor suppressor Rb
2013 · M R Reynolds, A N Lane, et al. · Oncogene · 215
The Envelope Glycoprotein of Human Endogenous Retrovirus Type W Uses a Divergent Family of Amino Acid Transporters/Cell Surface Receptors
2002 · Dimitri Lavillette, Mariana Marin, et al. · Journal of Virology · 209
SLC transporters: structure, function, and drug discovery
2016 · Claire Colas, Peter Man-Un Ung, et al. · MedChemComm · 203
Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth
2017 · Mariafrancesca Scalise, Lorena Pochini, et al. · Frontiers in Oncology · 182
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Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes
2006 · Zhaobao Yin, Dejan Milatovic, et al. · Brain Research · 181
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
2020 · Haojie Jin, Siying Wang, et al. · eLife · 178
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
2018 · Yann Cormerais, Pierre André Massard, et al. · Journal of Biological Chemistry · 176
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Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
2016 · Marina Bolzoni, Martina Chiu, et al. · Blood · 176
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Works count: 879
Citation count: 24,740
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