Keyword

ATF4

Description: A transcription factor encoded by a human gene that regulates cellular stress responses, metabolism, and related gene expression.

Primary topic: Endoplasmic Reticulum Stress and Disease (30%)

Wikidata ID: wiki/Q17832657

OpenAlex ID: keywords/atf4

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 · Heather P. Harding, Yuhong Zhang, et al. · Molecular Cell · 3,326

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 · Heather P Harding, Isabel Novoa, et al. · Molecular Cell · 3,278

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The integrated stress response

2016 · Karolina Pakos‐Zebrucka, Izabela Koryga, et al. · EMBO Reports · 2,640

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

2004 · Krishna M. Vattem, Ronald C. Wek · Proceedings of the National Academy of Sciences · 1,691

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

2013 · Jaeseok Han, Sung Hoon Back, et al. · Nature Cell Biology · 1,686

Coping with stress: eIF2 kinases and translational control

2006 · R.C. Wek, H.-Y. Jiang, et al. · Biochemical Society Transactions · 1,289

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

2013 · Wafa B’chir, Anne-Catherine Maurin, et al. · Nucleic Acids Research · 1,155

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

2006 · Esther A. Obeng, Louise M. Carlson, et al. · Blood · 1,144

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Cell death induced by endoplasmic reticulum stress

2015 · Raffaella Iurlaro, Cristina Muñoz‐Pinedo · FEBS Journal · 1,065

Regulation of osteoblast differentiation by transcription factors

2006 · Toshihisa Komori · Journal of Cellular Biochemistry · 1,025

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TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

2005 · Nobumichi Ohoka, Satoshi Yoshii, et al. · The EMBO Journal · 1,016

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

2004 · Phoebe D. Lu, Heather P. Harding, et al. · The Journal of Cell Biology · 1,004

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The eIF2α kinases: their structures and functions

2013 · Neysan Donnelly, Adrienne M. Gorman, et al. · Cellular and Molecular Life Sciences · 859

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

2007 · D. R. Laybutt, A. M. Preston, et al. · Diabetologia · 829

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

2017 · Pedro M. Quirós, Miguel A. Prado, et al. · The Journal of Cell Biology · 828

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

2009 · Kasper M.A. Rouschop, Twan van den Beucken, et al. · Journal of Clinical Investigation · 826

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

2004 · Xiangli Yang, Koichi Matsuda, et al. · Cell · 820

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The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

2001 · Tsonwin Hai, Matthew G Hartman · Gene · 808

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

2016 · Issam Ben-Sahra, Gerta Hoxhaj, et al. · Science · 792

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

2012 · Kook Hwan Kim, Yeon Taek Jeong, et al. · Nature Medicine · 773

NRF2 regulates serine biosynthesis in non–small cell lung cancer

2015 · Gina M DeNicola, Pei-Hsuan Chen, et al. · Nature Genetics · 747

ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

2005 · Meixia Bi, Christine Naczki, et al. · The EMBO Journal · 730

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

2010 · Jiangbin Ye, Monika Kumanova, et al. · The EMBO Journal · 703

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Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 · Yanjun Ma, Joseph W. Brewer, et al. · Journal of Molecular Biology · 689

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

2020 · Xiaoyan Guo, Giovanni Aviles, et al. · Nature · 670

Works count: 6,245

Citation count: 196,300