Keyword

Axin

Description: A scaffold protein involved in Wnt signaling and other cellular processes, including regulation of β-catenin and organization of intracellular signaling complexes.

Primary topic: Wnt/β-catenin signaling in development and cancer (66%)

Wikidata ID: wiki/Q18032810

OpenAlex ID: keywords/axin

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 · Michael Shtutman, Jacob Zhurinsky, et al. · Proceedings of the National Academy of Sciences · 2,230

A role for Wnt signalling in self-renewal of haematopoietic stem cells

2003 · Tannishtha Reya, Andrew W. Duncan, et al. · Nature · 2,160

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

2002 · Chunming Liu, Yiming Li, et al. · Cell · 2,070

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Inhibition of Adipogenesis by Wnt Signaling

2000 · Sarah E. Ross, Nahid Hemati, et al. · Science · 1,876

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

2002 · Eek-hoon Jho, Tong Zhang, et al. · Molecular and Cellular Biology · 1,680

Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

2004 · Catriona H.M. Jamieson, Laurie E. Ailles, et al. · New England Journal of Medicine · 1,487

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Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

2009 · Baozhi Chen, Michael E Dodge, et al. · Nature Chemical Biology · 1,383

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

1998 · Satoshi Ikeda, Shosei Kishida, et al. · The EMBO Journal · 1,247

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AMPK: Sensing Glucose as well as Cellular Energy Status

2017 · Sheng-Cai Lin, D. Grahame Hardie · Cell Metabolism · 1,193

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The -Catenin Destruction Complex

2012 · J. L. Stamos, W. I. Weis · Cold Spring Harbor Perspectives in Biology · 1,056

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Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

2007 · Josipa Bilić, Ya-Lin Huang, et al. · Science · 935

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 · Li Zeng, François Fagotto, et al. · Cell · 908

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Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis

2005 · Maria Domenica Castellone, Hidemi Teramoto, et al. · Science · 883

The many ways of Wnt in cancer

2007 · Paul Polakis · Current Opinion in Genetics & Development · 868

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

2005 · Xin Zeng, Keiko Tamai, et al. · Nature · 849

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

2001 · Junhao Mao, Jiyong Wang, et al. · Molecular Cell · 840

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Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 · Matthew J. Hart, Rico de los Santos, et al. · Current Biology · 836

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Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

2002 · Sharon Amit, Ada Hatzubai, et al. · Genes & Development · 754

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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

2017 · Chen-Song Zhang, Simon A. Hawley, et al. · Nature · 721

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

2003 · Ethan Lee, Adrian Salic, et al. · PLoS Biology · 707

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A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 · Sheelagh Frame, Philip Cohen, et al. · Molecular Cell · 701

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Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

2012 · B. T. MacDonald, X. He · Cold Spring Harbor Perspectives in Biology · 614

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Pharmacological inhibitors of glycogen synthase kinase 3

2004 · L MEIJER, M FLAJOLET, et al. · Trends in Pharmacological Sciences · 584

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

2005 · Gary Davidson, Wei Wu, et al. · Nature · 581

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

2014 · Chen-Song Zhang, Bin Jiang, et al. · Cell Metabolism · 557

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Works count: 1,324

Citation count: 82,450