Get started
Keyword

Axin2

Description: A human gene encoding a scaffold protein that regulates canonical Wnt signaling and participates in cellular development and disease.
Wikidata ID: wiki/Q18032812
OpenAlex ID: keywords/axin2
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
2002 · Eek-hoon Jho, Tong Zhang, et al. · Molecular and Cellular Biology · 1,678
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
2002 · Barbara Lustig, Boris Jerchow, et al. · Molecular and Cellular Biology · 1,037
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
2013 · Jun Liu, Shifeng Pan, et al. · Proceedings of the National Academy of Sciences · 832
Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer
2004 · Laura Lammi, Sirpa Arte, et al. · The American Journal of Human Genetics · 691
PDF
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
2015 · Bruce Wang, Ludan Zhao, et al. · Nature · 674
A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells
2006 · Jong In Yook, Xiao-Yan Li, et al. · Nature Cell Biology · 617
Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis
2003 · Alexander Aulehla, Christian Wehrle, et al. · Developmental Cell · 593
PDF
Colorectal cancer and genetic alterations in the Wnt pathway
2006 · S Segditsas, I Tomlinson · Oncogene · 591
Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung
2017 · Jarod A. Zepp, William J. Zacharias, et al. · Cell · 564
PDF
Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
2002 · Ken Taniguchi, Lewis R Roberts, et al. · Oncogene · 486
Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland
2012 · Renée van Amerongen, Angela N. Bowman, et al. · Cell stem cell · 445
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
2011 · Nam Hee Kim, Hyun Sil Kim, et al. · The Journal of Cell Biology · 432
PDF
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
2011 · Yue Zhang, Shanming Liu, et al. · Nature Cell Biology · 431
Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture
2010 · Yi Arial Zeng, Roel Nusse · Cell stem cell · 396
PDF
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors
2001 · Dong Yan, Marion Wiesmann, et al. · Proceedings of the National Academy of Sciences · 367
The role of Axin2 in calvarial morphogenesis and craniosynostosis
2005 · Hsiao-Man Ivy Yu, Boris Jerchow, et al. · Development · 357
PDF
Long Noncoding RNA NEAT1 , Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/ β -Catenin Pathway by Scaffolding EZH2
2017 · Qun Chen, Jinquan Cai, et al. · Clinical Cancer Research · 356
Activation of AXIN2 Expression by β-Catenin-T Cell Factor
2002 · Janet Y. Leung, Frank T. Kolligs, et al. · Journal of Biological Chemistry · 352
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
2011 · Stephen P J Fancy, Emily P Harrington, et al. · Nature Neuroscience · 351
Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling
2013 · Xinhong Lim, Si Hui Tan, et al. · Science · 348
Regulation of gene expression by alternative untranslated regions
2006 · Thomas A. Hughes · Trends in Genetics · 334
Dental agenesis: genetic and clinical perspectives
2008 · P. J. De Coster, L. A. Marks, et al. · Journal of Oral Pathology and Medicine · 329
PDF
A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
2012 · Jo Waaler, Ondrej Machon, et al. · Cancer Research · 328
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
2006 · Ayyakannu Ayyanan, Gianluca Civenni, et al. · Proceedings of the National Academy of Sciences · 294
Genetic basis of tooth agenesis
2009 · Pekka Nieminen · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · 285
Works count: 2,185
Citation count: 57,720
Year
Topic
Type