Keyword

BACE1

Description: A beta-secretase enzyme that cleaves amyloid precursor protein and is studied in relation to Alzheimer’s disease and cellular signaling.

Primary topic: Alzheimer's disease research and treatments (67%)

Wikidata ID: wiki/Q737488

OpenAlex ID: keywords/bace1

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

2011 · Lydia Alvarez-Erviti, Yiqi Seow, et al. · Nature Biotechnology · 4,913

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

2008 · Mohammad Ali Faghihi, Farzaneh Modarresi, et al. · Nature Medicine · 1,416

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

2008 · Sébastien S. Hébert, Katrien Horré, et al. · Proceedings of the National Academy of Sciences · 1,181

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 · Robert Ehehalt, Patrick Keller, et al. · The Journal of Cell Biology · 1,107

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 · Huaibin Cai, Yanshu Wang, et al. · Nature Neuroscience · 1,065

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 · Yi Luo, Brad Bolon, et al. · Nature Neuroscience · 1,001

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1

2008 · Wang-Xia Wang, Bernard W. Rajeev, et al. · Journal of Neuroscience · 827

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Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

2011 · Y. Joy Yu, Yin Zhang, et al. · Science Translational Medicine · 789

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

2003 · Li-Bang Yang, Kristina Lindholm, et al. · Nature Medicine · 729

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

2018 · Ben Readhead, Jean-Vianney Haure-Mirande, et al. · Neuron · 705

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

2006 · Michael Willem, Alistair N. Garratt, et al. · Science · 702

The β-Secretase BACE1 in Alzheimer’s Disease

2020 · Harald Hampel, Robert Vassar, et al. · Biological Psychiatry · 692

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

2014 · Riqiang Yan, Robert Vassar · The Lancet Neurology · 630

Bace1 modulates myelination in the central and peripheral nervous system

2006 · Xiangyou Hu, Caitlin W Hicks, et al. · Nature Neuroscience · 608

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

2006 · Xiulian Sun, Guiqiong He, et al. · Proceedings of the National Academy of Sciences · 605

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

2009 · Robert Vassar, Dora M. Kovacs, et al. · Journal of Neuroscience · 576

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Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

2005 · Michael T. Heneka, Magdalena Sastre, et al. · Brain · 566

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The Alzheimer's disease Beta-secretase enzyme, BACE1

2007 · Sarah L Cole, Robert Vassar · Molecular Neurodegeneration · 548

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BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

2004 · Masuo Ohno, Evgeny A Sametsky, et al. · Neuron · 548

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BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

2005 · Fiona M. Laird, Huaibin Cai, et al. · Journal of Neuroscience · 521

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Evidence for natural antisense transcript-mediated inhibition of microRNA function

2010 · Mohammad Ali Faghihi, Ming Zhang, et al. · Genome biology · 520

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Current state of Alzheimer’s fluid biomarkers

2018 · José Luis Molinuevo, Scott Ayton, et al. · Acta Neuropathologica · 517

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Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

2014 · Irina A. Buhimschi, Unzila A. Nayeri, et al. · Science Translational Medicine · 475

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

2008 · Jinfang Wu, Md. Riyaz Basha, et al. · Journal of Neuroscience · 473

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APP processing is regulated by cytoplasmic phosphorylation

2003 · Ming-Sum Lee, Shih-Chu Kao, et al. · The Journal of Cell Biology · 454

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Works count: 5,282

Citation count: 158,900