Keyword

base editing

Description: A genome-editing method that changes individual DNA bases at targeted sites, generally without making double-strand breaks in DNA.

Primary topic: CRISPR and Genetic Engineering (67%)

OpenAlex ID: keywords/base-editing

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

2016 · Alexis C. Komor, Yongjoo B. Kim, et al. · Nature · 5,428

Search-and-replace genome editing without double-strand breaks or donor DNA

2019 · Andrew V. Anzalone, Peyton B. Randolph, et al. · Nature · 4,744

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

2017 · Nicole M. Gaudelli, Alexis C. Komor, et al. · Nature · 4,175

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

2018 · Zhen Liu, Zongyang Lu, et al. · Nature Communications · 2,076

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Base editing: precision chemistry on the genome and transcriptome of living cells

2018 · Holly A. Rees, David R. Liu · Nature Reviews Genetics · 1,670

CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture

2019 · Kunling Chen, Yanpeng Wang, et al. · Annual Review of Plant Biology · 1,578

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

2018 · Johnny H. Hu, Shannon M. Miller, et al. · Nature · 1,551

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

2020 · Russell T. Walton, Kathleen A. Christie, et al. · Science · 1,230

Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion

2017 · Yuan Zong, Yanpeng Wang, et al. · Nature Biotechnology · 868

Applications of CRISPR–Cas in agriculture and plant biotechnology

2020 · Haocheng Zhu, Chao Li, et al. · Nature Reviews Molecular Cell Biology · 867

Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

2017 · Zenpei Shimatani, Sachiko Kashojiya, et al. · Nature Biotechnology · 811

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

2017 · Alexis C. Komor, Kevin T. Zhao, et al. · Science Advances · 779

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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

2017 · Y Bill Kim, Alexis C Komor, et al. · Nature Biotechnology · 764

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

2019 · Benjamin P. Kleinstiver, Alexander A. Sousa, et al. · Nature Biotechnology · 689

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

2022 · Samagya Banskota, Aditya Raguram, et al. · Cell · 663

EditR: A Method to Quantify Base Editing from Sanger Sequencing

2018 · Mitchell G. Kluesner, Derek A. Nedveck, et al. · The CRISPR Journal · 565

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CRISPR/Cas System: Recent Advances and Future Prospects for Genome Editing

2019 · Hakim Manghwar, Keith Lindsey, et al. · Trends in Plant Science · 528

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Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

2020 · Jonathan M. Levy, Wei-Hsi Yeh, et al. · Nature Biomedical Engineering · 480

Base editing: advances and therapeutic opportunities

2020 · Elizabeth M. Porto, Alexis C. Komor, et al. · Nature Reviews Drug Discovery · 478

Glycosylase base editors enable C-to-A and C-to-G base changes

2020 · Dongdong Zhao, Ju Li, et al. · Nature Biotechnology · 464

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Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

2019 · Michael Xavier Doss, Agapios Sachinidis · Cells · 457

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Progress and prospects in plant genome editing

2017 · Kangquan Yin, Caixia Gao, et al. · Nature Plants · 433

PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

2021 · Sebastian M. Siegner, Mehmet E. Karasu, et al. · BMC Bioinformatics · 431

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Base editing with a Cpf1–cytidine deaminase fusion

2018 · Xiaosa Li, Ying Wang, et al. · Nature Biotechnology · 430

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

2017 · Holly A. Rees, Alexis C. Komor, et al. · Nature Communications · 426

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Works count: 2,891

Citation count: 75,980