Keyword

beta-cell dysfunction

Description: Impaired insulin-producing or regulatory activity of pancreatic beta cells, contributing to abnormal glucose control in diabetes and related conditions.

Primary topic: Pancreatic function and diabetes (45%)

OpenAlex ID: keywords/beta-cell-dysfunction

Mechanisms linking obesity to insulin resistance and type 2 diabetes

2006 · Steven E. Kahn, Rebecca L. Hull, et al. · Nature · 5,438

Prediabetes: a high-risk state for diabetes development

2012 · Adam G Tabák, Christian Herder, et al. · The Lancet · 2,945

Fetal and infant growth and impaired glucose tolerance at age 64.

1991 · C N Hales, D J Barker, et al. · BMJ · 2,711

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Type 2 diabetes: principles of pathogenesis and therapy

2005 · Michael Stumvoll, Barry J Goldstein, et al. · The Lancet · 2,661

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 · Ralph A DeFronzo · Diabetes · 2,460

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

2003 · S. E. Kahn · Diabetologia · 2,165

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Pathogenesis of NIDDM: A Balanced Overview

1992 · Ralph A DeFronzo, Riccardd C Bonadonna, et al. · Diabetes Care · 2,081

Inflammation in obesity, diabetes, and related disorders

2022 · Theresa V. Rohm, Daniel T. Meier, et al. · Immunity · 2,050

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

2014 · Nathalie Esser, Sylvie Legrand-Poels, et al. · Diabetes Research and Clinical Practice · 1,977

Summary and Recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus

2007 · Boyd E. Metzger, Thomas A. Buchanan, et al. · Diabetes Care · 1,910

The Pathophysiology of Gestational Diabetes Mellitus

2018 · Jasmine F Plows, Joanna L Stanley, et al. · International Journal of Molecular Sciences · 1,858

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Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus

2010 · Yutaka Seino, Kishio Nanjo, et al. · Journal of Diabetes Investigation · 1,772

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Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

2013 · Steven E Kahn, Mark E Cooper, et al. · The Lancet · 1,743

Islet cell failure in type 2 diabetes

2006 · M. Prentki · Journal of Clinical Investigation · 1,687

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Hypovitaminosis D is associated with insulin resistance and β cell dysfunction

2004 · Ken C Chiu, Audrey Chu, et al. · American Journal of Clinical Nutrition · 1,642

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Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

1996 · Kazuya Yamagata, Naohisa Oda, et al. · Nature · 1,614

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

2017 · Arun Chaudhury, Chitharanjan Duvoor, et al. · Frontiers in Endocrinology · 1,499

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Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

2003 · Joseph L. Evans, Ira D. Goldfine, et al. · Diabetes · 1,483

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Oxidative stress, insulin signaling, and diabetes

2010 · Justin L. Rains, Sushil K. Jain · Free Radical Biology and Medicine · 1,437

Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited

2004 · Antonio Ceriello, Enrico Motz · Arteriosclerosis Thrombosis and Vascular Biology · 1,378

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Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2002 · Gary F. Lewis, André Carpentier, et al. · Endocrine Reviews · 1,334

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

2010 · Sheau-Fang Ng, Ruby C. Y. Lin, et al. · Nature · 1,325

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

2002 · G. Boden, G. I. Shulman · European Journal of Clinical Investigation · 1,301

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

2015 · Surapon Tangvarasittichai · World Journal of Diabetes · 1,214

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Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

2001 · Stefan S. Fajans, Graeme I. Bell, et al. · New England Journal of Medicine · 1,129

Works count: 11,280

Citation count: 351,500