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Keyword

BRCA2

Description: BRCA2 is a human tumor-suppressor gene that encodes a protein involved in DNA repair by homologous recombination.
OpenAlex ID: keywords/brca2
Integrated genomic analyses of ovarian carcinoma
2019 · Perou, Charles · Carolina Digital Repository (University of North Carolina at Chapel Hill) · 7,924
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 · Hannah Farmer, Nuala McCabe, et al. · Nature · 6,659
Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies
2003 · A. Antoniou, P.D.P. Pharoah, et al. · The American Journal of Human Genetics · 3,684
Identification of the breast cancer susceptibility gene BRCA2
1995 · Richard Wooster, Graham Bignell, et al. · Nature · 3,647
Integrative Clinical Genomics of Advanced Prostate Cancer
2015 · Dan Robinson, Eliezer M. Van Allen, et al. · Cell · 3,635
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Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
1998 · D. Ford, D.F. Easton, et al. · The American Journal of Human Genetics · 3,039
PARP inhibitors: Synthetic lethality in the clinic
2017 · Christopher J. Lord, Alan Ashworth · Science · 2,893
Whole genomes redefine the mutational landscape of pancreatic cancer
2015 · Australian Pancreatic Cancer Genome Initiative, Nicola Waddell, et al. · Nature · 2,643
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Pancreatic cancer
2020 · Jonathan D Mizrahi, Rishi Surana, et al. · The Lancet · 2,546
DNA double-strand breaks: signaling, repair and the cancer connection
2001 · Kum Kum Khanna, Stephen P. Jackson · Nature Genetics · 2,454
The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews
1997 · Jeffery P. Struewing, Patricia Hartge, et al. · New England Journal of Medicine · 2,281
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Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
2003 · Mary-Claire King, Joan H. Marks, et al. · Science · 2,229
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
2016 · Serena Nik-Zainal, Helen Davies, et al. · Nature · 2,216
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Epithelial ovarian cancer
2019 · Stephanie Lheureux, Charlie Gourley, et al. · The Lancet · 1,945
Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13
1994 · Richard Wooster, Susan L. Neuhausen, et al. · Science · 1,924
Mutational Processes Molding the Genomes of 21 Breast Cancers
2012 · Serena Nik-Zainal, Ludmil B. Alexandrov, et al. · Cell · 1,907
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Meta-Analysis of BRCA1 and BRCA2 Penetrance
2007 · Sining Chen, Giovanni Parmigiani · Journal of Clinical Oncology · 1,801
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
2002 · Ashok R. Venkitaraman · Cell · 1,713
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Mechanism of Eukaryotic Homologous Recombination
2008 · Joseph San Filippo, Patrick Sung, et al. · Annual Review of Biochemistry · 1,683
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer
2016 · Colin C. Pritchard, Joaquin Mateo, et al. · New England Journal of Medicine · 1,680
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Hallmarks of 'BRCAness' in sporadic cancers
2004 · Nicholas Turner, Andrew Tutt, et al. · Nature reviews. Cancer · 1,660
Breast cancer
2021 · Sibylle Loibl, Philip Poortmans, et al. · The Lancet · 1,657
Cancer Risks in BRCA2 Mutation Carriers
1999 · The Breast Cancer Linkage Consortium · JNCI Journal of the National Cancer Institute · 1,528
Targeting the DNA Damage Response in Cancer
2015 · Mark J. O’Connor · Molecular Cell · 1,524
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
2018 · Yixiao Feng, Mia Spezia, et al. · Genes & Diseases · 1,490
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Works count: 23,280
Citation count: 529,900
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