Keyword

BRCA2 mutation

Description: A BRCA2 mutation is a genetic variant in the BRCA2 gene that can affect DNA repair and influence inherited cancer risk.

Primary topic: BRCA gene mutations in cancer (57%)

Wikidata ID: wiki/Q28444961

OpenAlex ID: keywords/brca2-mutation

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

2016 · Willy Hugo, Jesse M. Zaretsky, et al. · Cell · 3,438

PDF

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

2016 · Nicolas Mottet, Joaquim Bellmunt, et al. · European Urology · 3,228

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

2018 · Kathleen Moore, Nicoletta Colombo, et al. · New England Journal of Medicine · 2,864

PDF

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

2010 · M William Audeh, James Carmichael, et al. · The Lancet · 2,278

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial

2017 · Eric Pujade-Lauraine, Jonathan A Ledermann, et al. · The Lancet Oncology · 1,856

Gene-Expression Profiles in Hereditary Breast Cancer

2001 · Ingrid Hedenfalk, David Duggan, et al. · New England Journal of Medicine · 1,733

Adjuvant Olaparib for Patients with BRCA1 - or BRCA2 -Mutated Breast Cancer

2021 · Andrew N.J. Tutt, Judy E. Garber, et al. · New England Journal of Medicine · 1,723

PDF

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

2010 · Andrew Tutt, Mark Robson, et al. · The Lancet · 1,658

Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations

2002 · Timothy R. Rebbeck, Henry T. Lynch, et al. · New England Journal of Medicine · 1,465

Risk-Reducing Salpingo-oophorectomy in Women with aBRCA1orBRCA2Mutation

2002 · Noah D. Kauff, Jaya M. Satagopan, et al. · New England Journal of Medicine · 1,251

PDF

Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

2004 · Timothy R. Rebbeck, Tara Friebel, et al. · Journal of Clinical Oncology · 1,174

Surveillance of BRCA1 and BRCA2 Mutation Carriers With Magnetic Resonance Imaging, Ultrasound, Mammography, and Clinical Breast Examination

2004 · Ellen Warner · JAMA · 1,169

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

2011 · Karen A Gelmon, Marc Tischkowitz, et al. · The Lancet Oncology · 1,117

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

2008 · Wataru Sakai, Elizabeth M. Swisher, et al. · Nature · 1,085

Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer

2006 · Bruce G. Haffty, Qifeng Yang, et al. · Journal of Clinical Oncology · 1,085

PDF

Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval

2010 · Peter C. Fong, Timothy A. Yap, et al. · Journal of Clinical Oncology · 1,011

PDF

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 · Mary Ellen Moynahan, Andrew J Pierce, et al. · Molecular Cell · 1,006

PDF

Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer

2001 · Harvey A. Risch, John R. McLaughlin, et al. · The American Journal of Human Genetics · 986

PDF

Breast Cancer after Prophylactic Bilateral Mastectomy in Women with aBRCA1orBRCA2Mutation

2001 · Hanne Meijers-Heijboer, Bert van Geel, et al. · New England Journal of Medicine · 976

PDF

Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients With Early-Onset Breast Cancer

1999 · J. Peto, N. Collins, et al. · JNCI Journal of the National Cancer Institute · 873

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1996 · S.V. Tavtigian, J. Simard, et al. · Nature Genetics · 839

The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2

2002 · Sunil R. Lakhani, Marc J. van de Vijver, et al. · Journal of Clinical Oncology · 823

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

2019 · Minsuh Kim, Hyemin Mun, et al. · Nature Communications · 811

PDF

Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2

2001 · Mary-Claire King · JAMA · 776

Male breast cancer

2006 · Ian S Fentiman, Alain Fourquet, et al. · The Lancet · 775

Works count: 5,713

Citation count: 146,000