Keyword

BRD3

Description: A human protein-coding gene encoding a member of the bromodomain and extra-terminal family, involved in chromatin regulation and gene expression.

Primary topic: Protein Degradation and Inhibitors (62%)

Wikidata ID: wiki/Q18032701

OpenAlex ID: keywords/brd3

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

2011 · Shaila Rahman, Mathew E. Sowa, et al. · Molecular and Cellular Biology · 528

BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells

2007 · C A French, C L Ramirez, et al. · Oncogene · 441

Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study

2016 · Céline Berthon, Emmanuel Raffoux, et al. · The Lancet Haematology · 420

Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study

2016 · Sandy Amorim, Anastasios Stathis, et al. · The Lancet Haematology · 417

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

2019 · Michael J. Roy, Sandra Winkler, et al. · ACS Chemical Biology · 373

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The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription

2008 · Gary LeRoy, Brenden Rickards, et al. · Molecular Cell · 372

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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

2016 · Yasushi Taniguchi · International Journal of Molecular Sciences · 336

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

2011 · Chun-wa Chung, Hervé Coste, et al. · Journal of Medicinal Chemistry · 334

PHOTACs enable optical control of protein degradation

2020 · Martin Reynders, Bryan S. Matsuura, et al. · Science Advances · 324

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

2013 · Olivier Mirguet, Romain Gosmini, et al. · Journal of Medicinal Chemistry · 305

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

2017 · Pingzhao Zhang, Dejie Wang, et al. · Nature Medicine · 297

The BET family in immunity and disease

2021 · Nian Wang, Runliu Wu, et al. · Signal Transduction and Targeted Therapy · 288

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Clinical trials for BET inhibitors run ahead of the science

2016 · Guillaume Andrieu, Anna C. Belkina, et al. · Drug Discovery Today Technologies · 245

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes

2011 · Janine M. Lamonica, Wulan Deng, et al. · Proceedings of the National Academy of Sciences · 239

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

2015 · Lei-lei Fu, Mao Tian, et al. · Oncotarget · 221

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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

2017 · Hana Janouskova, Geniver El Tekle, et al. · Nature Medicine · 186

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

2013 · Jan De Rijck, Christine de Kogel, et al. · Cell Reports · 175

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

2018 · Jean-Philippe Lambert, Sarah Picaud, et al. · Molecular Cell · 174

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

2013 · Jessica I. Spiltoir, Matthew S. Stratton, et al. · Journal of Molecular and Cellular Cardiology · 172

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

2014 · Kerstin Klein, Pawel A Kabala, et al. · Annals of the Rheumatic Diseases · 167

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

2020 · Kaveh Daneshvar, M. Behfar Ardehali, et al. · Nature Cell Biology · 163

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microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network

2010 · Liming Zhang, Tan Deng, et al. · Carcinogenesis · 153

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

2021 · Jieli Wei, Fanye Meng, et al. · Journal of the American Chemical Society · 146

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

2013 · Saumya Shree Gupta, Tobias Maetzig, et al. · Journal of Virology · 139

A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

2016 · Thomas C. R. Miller, Bernd Simon, et al. · Nature Communications · 132

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Works count: 525

Citation count: 12,450